ArticleProceedings of the National Academy of Sciences of the United States of America1988
Rapid detection of human chromosome 21 aberrations by in situ hybridization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 249 citations in OpenAlex.
- Preimplantation Genetic Testing for Genetic Diseases: Limits and Review of Current Literature.Genes · 2023Review
- Spatial RNA sequencing methods show high resolution of single cell in cancer metastasis and the formation of tumor microenvironment.Bioscience reports · 2023Review
- Plant 3D genomics: the exploration and application of chromatin organization.The New phytologist · 2021Review
- Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspective.Frontiers in cell and developmental biology · 2021Review
- Plant Chromosome-Specific Probes by Microdissection of a Single Chromosome: Is That a Reality?Frontiers in plant science · 2020Article
- Recollections of a scientific journey published in human genetics: from chromosome territories to interphase cytogenetics and comparative genome hybridization.Human genetics · 2014Article
- The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Seminars in cell & developmental biology · 2013Review
- Rapid-prenatal diagnosis through fluorescence in situ hybridization for preventing aneuploidy related birth defects.Indian journal of human genetics · 2013Article
- Cell cycle activation and aneuploid neurons in Alzheimer's disease.Molecular neurobiology · 2012Review
- Array CGH defined interstitial deletion on chromosome 14: a new case.European journal of pediatrics · 2010Article
- Chromosome territories.Cold Spring Harbor perspectives in biology · 2010Review
- Chromatin dynamics.Annual review of biophysics · 2010Review
- Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons.International journal of molecular sciences · 2009Review
- Misbehaviour of XIST RNA in breast cancer cells.PloS one · 2009Article
- The genome and the nucleus: a marriage made by evolution. Genome organisation and nuclear architecture.Chromosoma · 2005Review
- The molecular structure of the DNA fragments eliminated during chromatin diminution in Cyclops kolensis.Genome research · 2004Article
- Reverse painting highlights the origin of chromosome aberrations.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- Prenatal detection of aneuploidies using fluorescence in situ hybridization: a preliminary experience in an Indian set up.Journal of biosciences · 2002Article
- High-resolution physical and genetic mapping of the critical region for Meckel syndrome and Mulibrey Nanism on chromosome 17q22-q23.Genome research · 1999Article
- Demystified ... FISH.Molecular pathology : MP · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Plasmid clones containing up to 94 kilobases of single-copy DNA from band q22.3 of chromosome 21 and a complete pool of insert DNA from a chromosome 21 recombinant library have been used to rapidly detect numerical and structural aberrations of chromosome 21 by in situ hybridization in both metaphase and interphase cells. A trisomic karyotype, diagnostic of Down syndrome, is readily detected in nonmitotic cells because the majority of their nuclei exhibit three discrete foci of hybridization, in contrast to normal diploid cells, which show two foci. Chromosomal translocations involving chromosome 21 sequences were also detected with these probes, and the intranuclear location of 21q22.3 DNA sequences in "normal" human brain neurons was established with the plasmid DNA probe set. These results suggest that chromosome 21-specific probes may have utility in clinical diagnostics, especially by facilitating the direct analysis of interphase cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.