Evidence map›Paper›PMID 29741477›Full record

ArticleeLife2018

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8

Jie Geng, John D Altman, Sujatha Krishnakumar, Malini Raghavan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Article
  8. Open MHC Class I Conformers: A Look through the Looking Glass.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. CD8αα homodimers function as a coreceptor for KIR3DL1.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Radiotherapy activates autophagy to increase CD8The Journal of international medical research · 2019
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jie GengDepartment of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, United States.ORCID http://orcid.org/0000-0001-8722-2228
John D AltmanDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, United States.ORCID http://orcid.org/0000-0001-9733-2359
Sujatha KrishnakumarSirona Genomics, Immucor, Inc., California, United States.ORCID http://orcid.org/0000-0003-1961-3432
Malini RaghavanDepartment of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, United States.ORCID http://orcid.org/0000-0002-1345-9318
Michigan Medicine · USEmory University · USImmucor (United States) · US

Funding

INTERACTIONS &MECHANISMS OF FUNCTION OF THE TAP COMPLEXR01AI044115 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MALINI RAGHAVAN · 1999 to 2026
$9.3M
Interactions and mechanisms of function of the TAP ComplexR56AI044115 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAGHAVAN, MALINI · 2008 to 2008
$386k
NIAID NIH HHS AI044115NIAID NIH HHS R01 AI044115NIAID NIH HHS R01AI044115
6 · The paper itself

Abstract

When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8

Indexed as

CD8 AntigensCD8-Positive T-LymphocytesCells, CulturedHLA-B27 AntigenHumansLeukocytes, MononuclearProtein BindingCD8 AntigensHLA-B27 AntigenHLA-B protein, humanCD8empty HLAHLA-BHLA-B*35:01HLA class Ihumanimmunological synapseimmunologyinflammation

Identifiers

PMID29741477
PMCPMC5990358
OpenAlexW2802471001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.