ReviewAnnals of the New York Academy of Sciences2018
Persistent effects of obesity: a neuroplasticity hypothesis.
Review in Annals of the New York Academy of Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Central nervous system adaptation mechanism of obesity induced by high-fat high-sucrose diet: Differences in brain function between obese and obese resistant rats based on fMRI.Metabolism open · 2026Article
- Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.Translational psychiatry · 2026Article
- Overexpression of the short isoform of the dopamine D2 receptor causes diet-induced obesity and hyperglycemia in mice.Journal of neuroendocrinology · 2025Article
- A simple action reduces high-fat diet intake and obesity in mice.Current biology : CB · 2025Article
- Effects of diet and ovariectomy onBrain communications · 2025Article
- The best exercises from top 20 by health-related indicators.Frontiers in public health · 2025Article
- Self-rated health habits, mental health, emotional intelligence, and impulsivity across the Baltic States.Frontiers in public health · 2025Article
- Diet-Induced Obesity Induces Transcriptomic Changes in Neuroimmunometabolic-Related Genes in the Striatum and Olfactory Bulb.International journal of molecular sciences · 2024Article
- Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens DBiological psychiatry · 2024Article
- Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.Nature communications · 2024Article
- Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice.Nature communications · 2024Article
- Review
- Dynamic regulation of the extracellular matrix in reward memory processes: a question of time.Frontiers in cellular neuroscience · 2023Review
- The First Wave of the COVID-19 Pandemic Strengthened the "Strong" and Weakened the "Weak" Ones.International journal of environmental research and public health · 2022Article
- The Nexus between Pollution and Obesity and the Magnifying Role of Media Consumption: International Evidence from GMM Systems Estimates.International journal of environmental research and public health · 2022Article
- Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice.Translational psychiatry · 2022Article
- The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia.Genes · 2022Article
- Do Physical Activity, BMI, and Wellbeing Affect Logical Thinking?International journal of environmental research and public health · 2022Article
- Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers.Brain sciences · 2022Review
- Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus.Endocrine reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose weight through changes in diet and lifestyle, keeping the weight off remains a challenge. Here, we discuss a hypothesis that seeks to explain why obesity is so persistent. There is a great degree of overlap in the circuits implicated in substance use disorder and obesity, and neural plasticity of these circuits in response to drugs of abuse is well documented. We hypothesize that obesity is also associated with neural plasticity in these circuits, and this may underlie persistent changes in behavior, energy balance, and body weight. Here, we discuss how obesity-associated reductions in motivation and physical activity may be rooted in neurophysiological alterations in these circuits. Such plasticity may alter how humans and animals use, expend, and store energy, even after weight loss.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.