Evidence map›Paper›PMID 29741150›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.

Nguyen Ngoc Quang, Marina Chavchich, Chu Xuan Anh, Geoffrey W Birrell, Karin van Breda, Thomas Travers, Kerryn Rowcliffe, Michael D Edstein

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05203744 (Safety, Tolerability and Pharmacokinetics of Tafenoquine After Weekly and Escalating Monthly Doses of Tafenoquine in Healthy Vietnamese Volunteers), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05203744 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Safety, Tolerability and Pharmacokinetics of Tafenoquine After Weekly and Escalating Monthly Doses of Tafenoquine in Healthy Vietnamese Volunteers

TypeinterventionalSponsorNaval Medical Research CenterRan2022 to 2022Enrolled200ConditionsProphylaxisArmsTafenoquine prophylaxis
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Pharmacokinetics andAntimicrobial agents and chemotherapy · 2020
    Trial
  4. Review
  5. Review
  6. Virtual andACS pharmacology & translational science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nguyen Ngoc QuangInstitute for Clinical Infectious Diseases, Central Military Hospital 108, Hanoi, Vietnam.
Marina ChavchichDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
Chu Xuan AnhInstitute for Clinical Infectious Diseases, Central Military Hospital 108, Hanoi, Vietnam.
Geoffrey W BirrellDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
Karin van BredaDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
Thomas TraversDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
Kerryn RowcliffeDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
Michael D EdsteinDepartment of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia.
108 Military Central Hospital · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmacokinetics (PK) and ex vivo activity (pharmacodynamics [PD]) of two artemisinin combination therapies (ACTs) (artemisinin-piperaquine [ARN-PPQ] [Artequick

Indexed as

AmodiaquineAntimalarialsArea Under CurveArtemisininsBiotransformationDrug Administration ScheduleDrug CombinationsHalf-LifeHealthy VolunteersHumansMalaria, FalciparumMaleParasitic Sensitivity TestsPiperazinesPlasmodium falciparumQuinolinesAmodiaquineamodiaquine, artesunate drug combinationAntimalarialsartemisininArtemisininsartenimoldesethylamodiaquineDrug CombinationspiperaquinePiperazinesQuinolinesTablets

Identifiers

PMID29741150
PMCPMC6085815
OpenAlexW2800508171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.