ArticleHuman brain mapping2018
White matter tract network disruption explains reduced conscientiousness in multiple sclerosis.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- MRI Correlates of Depression and Anxiety in Multiple Sclerosis.Diseases (Basel, Switzerland) · 2026Review
- Linking Personality Traits to Disability Progression in Multiple Sclerosis: A Longitudinal Analysis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Neuroimaging assessment of facility-bound severely-affected MS reveals the critical role of cortical gray matter pathology: results from the CASA-MS case-controlled study.Journal of neurology · 2024Article
- Multiple sclerosis and personality traits: associations with depression and anxiety.European journal of medical research · 2024Article
- The sequence of regional structural disconnectivity due to multiple sclerosis lesions.Brain communications · 2023Article
- Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Functional network dynamics and decreased conscientiousness in multiple sclerosis.Journal of neurology · 2022Article
- The Big Five Personality Traits and Positive Orientation in Polish Adults with Multiple Sclerosis: The Role of Meaning in Life.International journal of environmental research and public health · 2022Article
- Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis.Brain and behavior · 2021Article
- Diagnosis of depression in multiple sclerosis is predicted by frontal-parietal white matter tract disruption.Journal of neurology · 2021Article
- Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis.Human brain mapping · 2019Article
- Cognitive Impairment in Multiple Sclerosis Is Reflected by Increased Susceptibility to the Sound-Induced Flash Illusion.Frontiers in neurology · 2019Article
- White matter tract network disruption explains reduced conscientiousness in multiple sclerosis.Human brain mapping · 2018Article
- Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study.AJNR. American journal of neuroradiology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantifying white matter (WM) tract disruption in people with multiple sclerosis (PwMS) provides a novel means for investigating the relationship between defective network connectivity and clinical markers. PwMS exhibit perturbations in personality, where decreased Conscientiousness is particularly prominent. This trait deficit influences disease trajectory and functional outcomes such as work capacity. We aimed to identify patterns of WM tract disruption related to decreased Conscientiousness in PwMS. Personality assessment and brain MRI were obtained in 133 PwMS and 49 age- and sex-matched healthy controls (HC). Lesion maps were applied to determine the severity of WM tract disruption between pairs of gray matter regions. Next, the Network-Based-Statistics tool was applied to identify structural networks whose disruption negatively correlates with Conscientiousness. Finally, to determine whether these networks explain unique variance above conventional MRI measures and cognition, regression models were applied controlling for age, sex, brain volume, T2-lesion volume, and cognition. Relative to HCs, PwMS exhibited lower Conscientiousness and slowed cognitive processing speed (p = .025, p = .006). Lower Conscientiousness in PwMS was significantly associated with WM tract disruption between frontal, frontal-parietal, and frontal-cingulate pathways in the left (p = .02) and right (p = .01) hemisphere. The mean disruption of these pathways explained unique additive variance in Conscientiousness, after accounting for conventional MRI markers of pathology and cognition (ΔR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.