ArticleScience advances2018
Light-sheet microscopy with attenuation-compensated propagation-invariant beams.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structuring light with flows.Nature communications · 2026Article
- On-demand generation of nondiffracting Helmholtz-Gauss laser beams.Scientific reports · 2025Article
- Zebrafish fluorescence imaging platform based on Bessel light sheet illumination.Biomedical optics express · 2025Article
- Sidelobe suppressed Bessel beams for one-photon light-sheet microscopy.Biomedical optics express · 2024Article
- Megahertz multi-parametric ophthalmic OCT system for whole eye imaging.Biomedical optics express · 2024Article
- Acoustic diffraction-resistant adaptive profile technology (ADAPT) for elasticity imaging.Science advances · 2023Article
- Spatially offset optical coherence tomography: Leveraging multiple scattering for high-contrast imaging at depth in turbid media.Science advances · 2023Article
- Challenges and advances in optical 3D mesoscale imaging.Journal of microscopy · 2022Article
- Space-Time Wave Packets from Smith-Purcell Radiation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- In vivo NIR-II structured-illumination light-sheet microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research.Pharmaceutics · 2020Review
- The Complex Charge Paradigm: A New Approach for Designing Electromagnetic Wavepackets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Airy-beam tomographic microscopy.Optica · 2020Article
- Multi-photon attenuation-compensated light-sheet fluorescence microscopy.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scattering and absorption limit the penetration of optical fields into tissue. We demonstrate a new approach for increased depth penetration in light-sheet microscopy: attenuation-compensation of the light field. This tailors an exponential intensity increase along the illuminating propagation-invariant field, enabling the redistribution of intensity strategically within a sample to maximize signal and minimize irradiation. A key attribute of this method is that only minimal knowledge of the specimen transmission properties is required. We numerically quantify the imaging capabilities of attenuation-compensated Airy and Bessel light sheets, showing that increased depth penetration is gained without compromising any other beam attributes. This powerful yet straightforward concept, combined with the self-healing properties of the propagation-invariant field, improves the contrast-to-noise ratio of light-sheet microscopy up to eightfold across the entire field of view in thick biological specimens. This improvement can significantly increase the imaging capabilities of light-sheet microscopy techniques using Airy, Bessel, and other propagation-invariant beam types, paving the way for widespread uptake by the biomedical community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.