Evidence map›Paper›PMID 29740590›Full record

ArticleFrontiers in cardiovascular medicine2018

Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort.

Wangjing Ke, Kristin A Rand, David V Conti, Veronica W Setiawan, Daniel O Stram, Lynne Wilkens, Loic Le Marchand, Themistocles L Assimes, Christopher A Haiman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Bangladeshi Atherosclerosis Biobank and Hub: The BANGABANDHU Study.International journal of general medicine · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Lysolipids in Vascular Development, Biology, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Wangjing KeDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, United States.
Kristin A RandAncestry, San Francisco, CA , United States.
David V ContiDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, United States.
Veronica W SetiawanDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, United States.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, United States.
Lynne WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, United States.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, United States.
Keck Hospital of USC · USStanford University · USUniversity of Hawaiʻi at Mānoa · USUniversity of Hawaii System · US

Funding

Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Epidemiologic Studies of Putative Functional Variation in Multiethnic CohortU01HG007397 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2013 to 2017
$3.7M
NCI NIH HHS U01 CA164973NHGRI NIH HHS U01 HG007397
6 · The paper itself

Abstract

backgroundCoronary heart disease (CHD) is the most common cause of death worldwide. Previous studies have identified numerous common CHD susceptibility loci, with the vast majority identified in populations of European ancestry. How well these findings transfer to other racial/ethnic populations remains unclear. METHODS AND

resultsWe examined the generalizability of the associations with 71 known CHD loci in African American, Latino and Japanese men and women in the Multiethnic Cohort (6,035 cases and 11,251 controls). In the combined multiethnic sample, 78% of the loci demonstrated odds ratios that were directionally consistent with those previously reported (

conclusionsWhile a sizable fraction of the known CHD loci appear to generalize in these populations, larger fine-mapping studies will be needed to localize the functional alleles and better define their contribution to CHD risk in these populations.

Indexed as

African Americanscoronary heart diseasegenome wide association study (GWAS)Japanese AmericansLatino Americanmulti-ethnicSORT1

Identifiers

PMID29740590
PMCPMC5931137
OpenAlexW2793191510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.