ReviewFrontiers in nutrition2018
Creatine Supplementation During Resistance Training Does Not Lead to Greater Bone Mineral Density in Older Humans: A Brief Meta-Analysis.
Review in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Exercise Improves Upper-Limb Bone Health in Women: A Systematic Review and Meta-Analysis of Exercise Type and Intensity.Current osteoporosis reports · 2026Pooled it
- Creatine in Health and Disease.Nutrients · 2021Pooled it
- Effects of Tai Chi and brisk walking on the bone mineral density of perimenopausal women: A randomized controlled trial.Frontiers in public health · 2022Trial
- Insufficient evidence to recommend creatine supplementation as a therapeutic option for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Mass Spectrometry Characterization of the Human Ankle and Hindfoot Fracture Microenvironment in Young and Aged Subjects.Indian journal of orthopaedics · 2024Article
- Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?Current osteoporosis reports · 2024Review
- Fueling the Firefighter and Tactical Athlete with Creatine: A Narrative Review of a Key Nutrient for Public Safety.Nutrients · 2024Review
- Creatine energy substrate increases bone density in the PahMolecular genetics and metabolism reports · 2023Article
- Nutrition and physical activity interventions for the general population with and without cardiometabolic risk: a scoping review.Public health nutrition · 2021Article
- Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations.Nutrients · 2021Review
- Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults.Nutrients · 2021Review
- Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring.Nutrients · 2019Article
- Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creatine supplementation during resistance training has potential beneficial effects on properties of bone in aging adults. We systematically reviewed randomized controlled trials (RCTs) investigating the effect of creatine supplementation combined with resistance training on bone mineral density (BMD) in aging adults. We searched PubMed and SPORTDiscus databases and included RCTs of ≥3 months duration that examined the combined effect of creatine and resistance training on bone mineral in adults >50 years of age or postmenopausal. Meta-analyses were performed when applicable trials were available on whole body and clinically important bone sites. Five trials met inclusion criteria with a total of 193 participants. Two of the studies reported significant benefits of creatine supplementation and resistance training compared to resistance training alone on bone. Meta-analyses revealed no greater effect of creatine and resistance training compared to resistance training alone on whole body BMD (MD: 0.00, 95% CI -0.01 to 0.01,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.