ArticleFrontiers in chemistry2018
Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors.
Article in Frontiers in chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Novel Au(I)- and Ag(I)-NHC Complexes withInternational journal of molecular sciences · 2025Article
- Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy.Animals : an open access journal from MDPI · 2025Review
- Efficacy of Novel Quaternary Ammonium and Phosphonium Salts Differing in Cation Type and Alkyl Chain Length against Antibiotic-ResistantInternational journal of molecular sciences · 2023Article
- Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to develop a new class of antimicrobial agents.Journal of advanced research · 2023Article
- Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Review
- Targeting Hydroxybenzoic Acids to Mitochondria as a Strategy to Delay Skin Ageing: An In Vitro Approach.Molecules (Basel, Switzerland) · 2022Article
- Flaxseed Ethanol Extracts' Antitumor, Antioxidant, and Anti-Inflammatory Potential.Antioxidants (Basel, Switzerland) · 2022Article
- Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant Molecule on Bovine Sperm Function and Embryo Production.Animals : an open access journal from MDPI · 2022Article
- A Report on Multi-Target Anti-Inflammatory Properties of Phytoconstituents fromMolecules (Basel, Switzerland) · 2021Article
- Tetrahydroxystilbene glucoside protects against sodium azide-induced mitochondrial dysfunction in human neuroblastoma cells.Chinese herbal medicines · 2021Article
- Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases.Antioxidants (Basel, Switzerland) · 2021Article
- Discovery of Helminthosporin, an Anthraquinone Isolated fromACS omega · 2020Article
- Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases.Current neuropharmacology · 2020Review
- Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials ofFrontiers in pharmacology · 2020Article
- Alzheimer's Disease Pharmacotherapy in Relation to Cholinergic System Involvement.Biomolecules · 2019Review
- Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-Up the Discovery of Chromone-Based Multitarget-Directed Ligands.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a multifactorial age-related disease associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS and restoring cholinergic transmission can be an effective therapeutic strategy toward AD. Herein, we report for the first time dual-target hydroxybenzoic acid (HBAc) derivatives acting as mitochondriotropic antioxidants and cholinesterase (ChE) inhibitors. The studies were performed with two mitochondriotropic antioxidants
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.