Evidence map›Paper›PMID 29740481›Full record

ArticleOncology letters2018

Long noncoding AFAP1-antisense RNA 1 is upregulated and promotes tumorigenesis in gastric cancer.

Fei Ye, Yi Gong, Xiangheng Chen, Meiying Yu, Zhongkun Zuo, Dongni Pei, Wei Liu, Qunwei Wang, Jun Zhou, Lunxi Duan and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Long Noncoding RNA (lncRNA) FOXD2-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Regulating MiR-185/AKT Axis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Fei YeDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Yi GongDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Xiangheng ChenDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Meiying YuDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Zhongkun ZuoDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Dongni PeiDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Wei LiuDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Qunwei WangDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Jun ZhouDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Lunxi DuanDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Leiyi ZhangDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Xiaojing LiDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Tenglong TangDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Jiangsheng HuangDepartment of Minimally Invasive Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNA serves important roles in gastric cancer (GC). However, the prognostic significance and tumorigenesis effect of AFAP1-antisense RNA 1 (AS1) in GC remain to be clarified. The present study was conducted in order to determine the expression level of AFAP1-AS1 by reverse transcription-quantitative polymerase chain reaction. It was demonstrated that AFAP1-AS1 expression level was higher in GC tissues in comparison with adjacent tissues. By analyzing 66 GC tissue specimens, AFAP1-AS1 expression level was found to be markedly associated with tumor size, clinical stage and differentiation. By performing multivariate Cox regression test, AFAP1-AS1 expression level was confirmed to be an independent factor for poor prognosis in patients with GC. Furthermore, SGC-7901 and BGC-823 cells were used for further investigation following transfection of an AFAP1-AS1 short hairpin RNA lentiviral vector. Knockdown of AFAP1-AS1 significantly inhibited GC cell proliferation, migration and invasion abilities

Indexed as

AFAP1-antisense RNA 1gastric cancerlong noncoding RNAprognosisproliferation

Identifiers

PMID29740481
PMCPMC5934723
OpenAlexW2792843933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.