Evidence map›Paper›PMID 29740432›Full record

ArticleFrontiers in immunology2018

Unique and Common Features of Innate-Like Human Vδ2

Nicholas M Provine, Benedikt Binder, Michael E B FitzPatrick, Anita Schuch, Lucy C Garner, Kate D Williamson, Bonnie van Wilgenburg, Robert Thimme, Paul Klenerman, Maike Hofmann

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 63 citations in OpenAlex.

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  15. An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nicholas M ProvineTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Benedikt BinderDepartment of Internal Medicine II, University Hospital Freiburg, Freiburg, Germany.
Michael E B FitzPatrickTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Anita SchuchDepartment of Internal Medicine II, University Hospital Freiburg, Freiburg, Germany.
Lucy C GarnerTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Kate D WilliamsonTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Bonnie van WilgenburgPeter Medawar Building for Pathogen Research, University of Oxford, Oxford, United Kingdom.
Robert ThimmeDepartment of Internal Medicine II, University Hospital Freiburg, Freiburg, Germany.
Paul KlenermanTranslational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Maike HofmannDepartment of Internal Medicine II, University Hospital Freiburg, Freiburg, Germany.
University of Oxford · GBUniversity Medical Center Freiburg · DEMedawar Building for Pathogen Research · GB

Funding

Medical Research CouncilWellcome Trust 109028/Z/15/ZWellcome Trust 109965/Z/15/ZWellcome Trust 200154/Z/15/ZWellcome Trust WT109965MA
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked to a transcriptional program that can be identified by the expression of the C-type lectin receptor, CD161. In addition to MAIT cells, it has been demonstrated that a subset of γδT cells expresses CD161 and can be activated by TCR-independent cytokine stimulation. In this study, we sought to clarify the nature of cytokine-responsive human γδT cells. We could link CD161 expression on Vδ2

Indexed as

AdultFemaleHepatitis C, ChronicHumansLymphocyte ActivationMaleMiddle AgedMucosal-Associated Invariant T CellsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, gamma-deltahepatitis C virusinnate-like T cellsmucosal-associated invariant Tmucosal immunologyVδ2 γδ T cellsγδ T cells

Identifiers

PMID29740432
PMCPMC5924964
OpenAlexW2799828422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.