Evidence map›Paper›PMID 29740425›Full record

ArticleFrontiers in immunology2018

Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8

Torben Knuschke, Olga Rotan, Wibke Bayer, Sebastian Kollenda, Julia Dickow, Kathrin Sutter, Wiebke Hansen, Ulf Dittmer, Karl S Lang, Matthias Epple and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Nanoparticle-Based Immunotherapy for Reversing T-Cell Exhaustion.International journal of molecular sciences · 2024
    Review
  6. Severe COVID-19European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  7. Article
  8. Article
  9. Biological and Medical Applications of Calcium Phosphate Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Torben KnuschkeInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Olga RotanInstitute of Inorganic Chemistry, Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Essen, Germany.
Wibke BayerInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sebastian KollendaInstitute of Inorganic Chemistry, Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Essen, Germany.
Julia DickowInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Kathrin SutterInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Wiebke HansenInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ulf DittmerInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Karl S LangInstitute for Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Matthias EppleInstitute of Inorganic Chemistry, Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Essen, Germany.
Jan BuerInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Astrid M WestendorfInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell dysfunction and immunosuppression are characteristic for chronic viral infections and contribute to viral persistence. Overcoming these burdens is the goal of new therapeutic strategies to cure chronic infectious diseases. We recently described that therapeutic vaccination of chronic retrovirus infected mice with a calcium phosphate (CaP) nanoparticle (NP)-based vaccine carrier, functionalized with CpG and viral peptides is able to efficiently reactivate the CD8

Indexed as

AnimalsCalcium PhosphatesCD8-Positive T-LymphocytesCell LineCytotoxicity, ImmunologicHumansInterferon Type IMiceMice, Inbred C57BLMice, KnockoutNanoparticlesReceptor, Interferon alpha-betaRetroviridaeRetroviridae InfectionsSignal TransductionVaccinationcalcium phosphateCalcium PhosphatesIfnar1 protein, mouseInterferon Type IReceptor, Interferon alpha-betaViral Vaccineschronic retrovirus infectioninterferon alphananoparticlesT cell immunitytherapeutic vaccinetype I interferons

Identifiers

PMID29740425
PMCPMC5924795
OpenAlexW2802758771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.