Evidence map›Paper›PMID 29740354›Full record

ArticleFrontiers in psychiatry2018

Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study.

Nian-Sheng Tzeng, Hsin-An Chang, Chi-Hsiang Chung, Yu-Chen Kao, Chuan-Chia Chang, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Shan-Yueh Chang, Wu-Chien Chien

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Early-life internalizing behavioral trajectories and childhood-onset asthma: An epigenetic link.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  3. Psychiatric Morbidity Following Intestinal Infectious Diseases: A Nationwide Cohort Study in South Korea.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
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  13. Acute Mountain Sickness and the Risk of Subsequent Psychiatric Disorders-A Nationwide Cohort Study in Taiwan.International journal of environmental research and public health · 2023
    Article
  14. Article
  15. Article
  16. Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nian-Sheng TzengDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Hsin-An ChangDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Chi-Hsiang ChungDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yu-Chen KaoDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Chuan-Chia ChangDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Hui-Wen YehDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Wei-Shan ChiangDepartment of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Yu-Ching ChouSchool of Public Health, National Defense Medical Center, Taipei, Taiwan.
Shan-Yueh ChangDivision of Chest and Critical Medicine, Department of Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Wu-Chien ChienDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
National Defense Medical Center · TWTri-Service General Hospital · TWTaiwan Nurses Association · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveAllergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan.

methodsThis cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000-2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray's competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up.

resultsOf the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (

conclusionAllergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan.

Indexed as

allergic rhinitisatopic dermatitisbronchial asthmacohort studyNational Health Insurance Research Databasepsychiatric disordersrisk factorsTaiwan National Health Insurance Program

Identifiers

PMID29740354
PMCPMC5928780
OpenAlexW2801026619

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.