ArticleFrontiers in physiology2018
Circulating miRNAs as Putative Biomarkers of Exercise Adaptation in Endurance Horses.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Exosome and miRNA Content Engagement in the Physical Exercise Response: What Is Known to Date in Atheltic Horses?International journal of molecular sciences · 2026Review
- Effects of hypoxia and hyperoxia on exercise-induced metabolomic and transcriptomic profiles in equine skeletal muscle.The Journal of experimental biology · 2025Article
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- Blood-Based Whole-Genome Methylation Analysis of Yili Horses Pre- and Post-Racing.Animals : an open access journal from MDPI · 2025Article
- Omic technology to monitoring resilience and adaptation to exercise and heat stress in endurance horses.Frontiers in veterinary science · 2025Article
- Comparative analysis of blood whole transcriptome profiles in Yili horses pre- and post-5000-meter racing.Frontiers in genetics · 2025Article
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- Use of Omics Data in Fracture Prediction; a Scoping and Systematic Review in Horses and Humans.Animals : an open access journal from MDPI · 2021Review
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- Conservation and novelty in the microRNA genomic landscape of hyperdiverse cichlid fishes.Scientific reports · 2019Article
- Expression analysis of miR-221-3p and its target genes in horses.Genes & genomics · 2019Article
- The Genetics of Racing Performance in Arabian Horses.International journal of genomics · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endurance exercise induces metabolic adaptations and has recently been reported associated with the modulation of a particular class of small noncoding RNAs, microRNAs, that act as post-transcriptional regulators of gene expression. Released into body fluids, they termed circulating miRNAs, and they have been recognized as more effective and accurate biomarkers than classical serum markers. This study examined serum profile of miRNAs through massive parallel sequencing in response to prolonged endurance exercise in samples obtained from four competitive Arabian horses before and 2 h after the end of competition. MicroRNA identification, differential gene expression (DGE) analysis and a protein-protein interaction (PPI) network showing significantly enriched pathways of target gene clusters, were assessed and explored. Our results show modulation of more than 100 miRNAs probably arising from tissues involved in exercise responses and indicating the modulation of correlated processes as muscle remodeling, immune and inflammatory responses. Circulating miRNA high-throughput sequencing is a promising approach for sports medicine for the discovery of putative biomarkers for predicting risks related to prolonged activity and monitoring metabolic adaptations.
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Registered trials
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