ArticleFrontiers in aging neuroscience2018
Reduced Dynamic Coupling Between Spontaneous BOLD-CBF Fluctuations in Older Adults: A Dual-Echo pCASL Study.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
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- Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging.Scientific reports · 2025Article
- The physiological basis underlying functional connectivity differences in older adults: A multi-modal analysis of resting-state fMRI.Brain imaging and behavior · 2022Article
- MRI-based clinical-radiomics model predicts tumor response before treatment in locally advanced rectal cancer.Scientific reports · 2021Article
- Osteopathy modulates brain-heart interaction in chronic pain patients: an ASL study.Scientific reports · 2021Article
- Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.Frontiers in neuroscience · 2020Article
- Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI.Frontiers in neuroscience · 2020Article
- A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer's Disease Data.Scientific reports · 2019Article
- Combination of three-dimensional arterial spin labeling and stretched-exponential model in grading of gliomas.Medicine · 2019Article
- Mild Propofol Sedation Reduces Frontal Lobe and Thalamic Cerebral Blood Flow: An Arterial Spin Labeling Study.Frontiers in physiology · 2019Article
- Cerebrovascular Resistance in Healthy Aging and Mild Cognitive Impairment.Frontiers in aging neuroscience · 2019Article
- Comparison of Resting-State Brain Activation Detected by BOLD, Blood Volume and Blood Flow.Frontiers in human neuroscience · 2018Article
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5 authors at 2 institutions in 1 country.
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Abstract
Measurement of the dynamic coupling between spontaneous Blood Oxygenation Level Dependent (BOLD) and cerebral blood flow (CBF) fluctuations has been recently proposed as a method to probe resting-state brain physiology. Here we investigated how the dynamic BOLD-CBF coupling during resting-state is affected by aging. Fifteen young subjects and 17 healthy elderlies were studied using a dual-echo pCASL sequence. We found that the dynamic BOLD-CBF coupling was markedly reduced in elderlies, in particular in the left supramarginal gyrus, an area known to be involved in verbal working memory and episodic memory. Moreover, correcting for temporal shift between BOLD and CBF timecourses resulted in an increased correlation of the two signals for both groups, but with a larger increase for elderlies. However, even after temporal shift correction, a significantly decreased correlation was still observed for elderlies in the left supramarginal gyrus, indicating that the age-related dynamic BOLD-CBF uncoupling in this region is more pronounced and can be only partially explained with a simple time-shift between the two signals. Interestingly, these results were observed in a group of elderlies with normal cognitive functions, suggesting that the study of dynamic BOLD-CBF coupling during resting-state is a promising technique, potentially able to provide early biomarkers of functional changes in the aging brain.
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