Evidence map›Paper›PMID 29740197›Full record

ArticleGenes and immunity2019

IKKα deficiency disrupts the development of marginal zone and follicular B cells.

Mumtaz Y Balkhi, Jami Willette-Brown, Gabor Wittmann, Yinling Hu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mumtaz Y BalkhiDivision of Hematology/Oncology, Department of Medicine, Tufts University School of Medicine, Boston, MA, USA. mumtaz.yaseen@tufts.edu.
Jami Willette-BrownCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, USA.
Gabor WittmannDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
Yinling HuCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, MD, USA.
Center for Cancer Research · USTufts University · US

Funding

Role of IKKalpha in lymphoid organ developmentZIABC011422 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HU, YINLING · 2012 to 2025
$4.4M
Intramural NIH HHS ZIA BC011422
6 · The paper itself

Abstract

Only few genes have been confidently identified to be involved in the Follicular (FO) and Marginal Zone (MZ) B cell differentiation, migration, and retention in the periphery. Our group previously observed that IKKα kinase inactive mutant mice IKKα

Indexed as

Cell DifferentiationAnimalsB-LymphocytesBone Marrow CellsCell LineageCell MovementCells, CulturedHepatocytesI-kappa B KinaseMiceSpleenI-kappa B Kinase

Identifiers

PMID29740197
PMCPMC8191388
OpenAlexW2800077603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.