ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Quality improvement initiative to improve inpatient outcomes for Neonatal Abstinence Syndrome.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Eat, Sleep, Console model for neonatal opioid withdrawal syndrome: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Non-pharmacological care for opioid withdrawal in newborns.The Cochrane database of systematic reviews · 2020Pooled it
- Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.The New England journal of medicine · 2023Trial
- Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.BMC pediatrics · 2022Trial
- A comparative study of two scoring systems for the assessment of neonatal abstinence syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- A Structural Examination of Racial Differences in Pharmacologic Treatment Among Opioid Exposed Infants.Journal of racial and ethnic health disparities · 2026Article
- A Roadmap to Improved Quality Outcomes in Neonates Exposed to Illegally Manufactured Fentanyl.Journal of pediatrics. Clinical practice · 2025Article
- A retrospective cohort study of neonatal abstinence syndrome patients following implementation of Eat Sleep Console Protocol.Paediatrics & child health · 2025Article
- The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains.Addiction neuroscience · 2025Article
- Impact of a Preclinical Elective on Medical Student Attitudes Toward People With Substance Use Disorders.PRiMER (Leawood, Kan.) · 2025Article
- Impact of a qualitative assessment approach for neonatal abstinence syndrome management: experience of a European reference center.Italian journal of pediatrics · 2024Article
- Neurobehavioral outcomes of infants exposed to buprenorphine-naloxone compared with naltrexone during pregnancy.Early human development · 2024Article
- Evaluating a web-based training curriculum for disseminating best practices for the care of newborns with neonatal opioid withdrawal syndrome in a rural hospital, the NOWS-NM Program.BMC pediatrics · 2024Article
- Evaluating the Impact of Eat, Sleep, Console in Neonatal Abstinence Syndrome Treatment for Infants Exposed to Substance UseThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Neonatal Abstinence Signs during Treatment: Trajectory, Resurgence and Heterogeneity.Children (Basel, Switzerland) · 2024Article
- Evaluating Epidemiologic Trends and Variations in NICU Admissions in California, 2008 to 2018.Hospital pediatrics · 2023Article
- Assessing the Eat, Sleep, Console model for neonatal abstinence syndrome management at a regional referral center.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Drivers of decision-making regarding infant sleep practices among mothers with opioid use disorder.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The Neonatal Withdrawal Assessment Tool (NWAT): pilot inter-rater reliability and content validity.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The Influence of Mediators on the Relationship Between Antenatal Opioid Agonist Exposure and the Severity of Neonatal Opioid Withdrawal Syndrome.Maternal and child health journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo improve Neonatal Abstinence Syndrome (NAS) inpatient outcomes through a comprehensive quality improvement (QI) program.
designInclusion criteria were opioid-exposed infants ≥36 weeks. QI methodology including stakeholder interviews and plan-do-study-act (PDSA) cycles were utilized. We compared pre- and post-intervention NAS outcomes after a QI initiative that included: A non-pharmacologic care bundle, function-based assessments consisting of symptom prioritization and then the "Eat, Sleep, Console" (ESC) Tool; and a switch to methadone for pharmacologic treatment.
resultsPharmacologic treatment decreased from 87.1 to 40.0%; adjunctive agent use from 33.6 to 2.4%; hospitalization length from a mean 17.4 to 11.3 days, and opioid treatment days from 16.2 to 12.7 (p < 0.001 for all). Total hospital charges decreased from $31,825 to $20,668 per infant. Parental presence increased from 55.6 to 75.8% (p < 0.0001). No adverse events were noted.
conclusionsA comprehensive QI program focused on non-pharmacologic care, function-based assessments, and methadone resulted in significant sustained improvements in NAS outcomes. These findings have important implications for establishing potentially better practices for opioid-exposed newborns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.