Evidence map›Paper›PMID 29740192›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2018

Safety of fentanyl for peripherally inserted central catheter in non-intubated infants in the neonatal intensive care unit.

Yair Kasirer, Vibhuti Shah, Eugene W Yoon, Ruben Bromiker, Carol Mcnair, Anna Taddio

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Yair KasirerNeonatal Intensive Care unit, Shaare Zedek Medical Center, Jerusalem, 9103102, Israel. yairkasirer@yahoo.com.
Vibhuti ShahDepartment of Paediatrics, Mount Sinai Hospital, Department of Paediatrics and Institute of Health Policy, Management and Evaluation, University of Toronto Rm 19-231N, 600 University Avenue, Toronto, ON, Canada.
Eugene W YoonMaternal-Infant Care Research Centre, Mount Sinai Hospital, 700 University Ave. Room 8-500, Toronto, ON, Canada.
Ruben BromikerDepartment of Neonatology, Schneider Children's Medical Center of Israel, 14 Kaplan St., Petach Tikva, 4920235, Israel.
Carol McnairDepartment of Neonatology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada.
Anna TaddioLeslie Dan Faculty of Pharmacy, 144 College Street, Toronto, ON, Canada.
Hospital for Sick Children · CAMount Sinai Hospital · CASchneider Children's Medical Center · ILShaare Zedek Medical Center · ILUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety of fentanyl in non-intubated infants undergoing peripherally inserted central catheter (PICC) placement.

methodsA retrospective chart review of PICC placements over a 3 years' period. We compared the 12h periods before and after fentanyl for clinically significant cardiorespiratory events (spells).

resultsOf the 998 neonates screened, 258 were eligible. The mean standard deviation gestational age was 34.1 (4.3) weeks and the median (inter-quartile range) postnatal age was 4 (7, 11) days. The mean (standard deviation) fentanyl dose was 0.6 (0.2) µg/kg. Respiratory depression occurred only in two infants (prevalence rate = 0.78%, 95% CI (0, 1.85)). No cases of hypotension or chest wall rigidity occurred. There was no evidence of an increase in the number of infants with spells or in the number of spells per infant (p = 0.34 and p = 0.06, respectively).

conclusionFentanyl appears to be associated with only a small risk of respiratory depression in non-intubated infants.

Indexed as

Catheterization, PeripheralIntensive Care, NeonatalAnalgesics, OpioidDatabases, FactualDevice RemovalFemaleFentanylGestational AgeHumansInfant, NewbornInfant, Very Low Birth WeightIntensive Care Units, NeonatalMalePrevalenceRespiratory RateRetrospective StudiesAnalgesics, OpioidFentanyl

Identifiers

PMID29740192
OpenAlexW2800811672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.