Evidence map›Paper›PMID 29740191›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2018

Neonatal outcomes of extremely preterm infants exposed to maternal hypertension and cigarette smoking.

Kamran Yusuf, Belal Alshaikh, Orlando da Silva, Abhay K Lodha, Robert D Wilson, Ruben E Alvaro, Shoo K Lee, Prakesh S Shah, Canadian Neonatal Network Investigators

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Preterm congenital heart disease and neurodevelopment: the importance of looking beyond the initial hospitalization.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kamran YusufDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. kyusuf@ucalgary.ca.ORCID 0000-0001-5270-5326
Belal AlshaikhDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Orlando da SilvaDepartment of Pediatrics, University of Western Ontario, London, ON, Canada.
Abhay K LodhaDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Robert D WilsonDepartment of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ruben E AlvaroDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Shoo K LeeDepartment of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Canadian Neonatal Network Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the outcomes of extremely preterm infants of hypertensive mothers who smoke. STUDY

designThis retrospective cohort study included infants born between 2003 and 2012 at <29 weeks' gestation and admitted to neonatal intensive care units participating in the Canadian Neonatal Network. Infants were divided into four mutually exclusive groups. Infants of hypertensive mothers who smoked; infants of hypertensive, non-smoking mothers; infants of normotensive mothers who smoked; and infants of normotensive, non-smoking mothers. Using infants of normotensive, non-smoking mothers as the reference group, neonatal outcomes were compared between the groups. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were calculated using univariate and multivariate regression analysis.

resultsOf the 12,307 eligible infants, 172 had hypertensive mothers who smoked, 1689 had hypertensive non-smoking mothers, 1535 had normotensive mothers who smoked, and 8911 had normotensive non-smoking mothers. Compared to infants of normotensive non-smoking mothers, infants of hypertensive mothers, regardless of smoking status, had higher odds of developing bronchopulmonary dysplasia (AORs of smokers 1.62; 95% CI 1.12-2.35 and of non-smokers 1.43; 95% CI 1.24-1.64). There was no difference in the odds of mortality and retinopathy of prematurity stage ≥3 between the groups. Infants of hypertensive, non-smoking mothers had decreased odds of intraventricular hemorrhage >grade 2 and higher odds of necrotizing enterocolitis. There was decreased odds of hypertension if the mother was a smoker (AOR 0.71; 95% CI 0.59-0.85).

conclusionMaternal hypertension is associated with increased rates of bronchopulmonary dysplasia, irrespective of smoking status.

Indexed as

Infant, Extremely PrematureInfant MortalityAdultBronchopulmonary DysplasiaCanadaCerebral HemorrhageCigarette SmokingDatabases, FactualEnterocolitis, NecrotizingFemaleGestational AgeHumansHypertension, Pregnancy-InducedInfantInfant, NewbornIntensive Care Units, Neonatal

Identifiers

PMID29740191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.