ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- [Role of fecal calprotectin in the diagnosis of neonatal necrotizing enterocolitis: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Pooled it
- Powdered human milk-derived versus bovine milk-derived breastmilk fortification: A multi-centre preterm randomised controlled trial.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Inflammatory Markers in Mother's Own Milk and Infant Stool of Very Low Birthweight Infants.Journal of human lactation : official journal of International Lactation Consultant Association · 2023Trial
- Biomarkers for Necrotising Enterocolitis-Are We There Yet?Children (Basel, Switzerland) · 2026Review
- Necrotizing Enterocolitis: What's New and What's Next?International journal of molecular sciences · 2025Review
- Intestinal Biomarkers in Preterm Infants: Influence of Mother's Own Milk on Fecal Calprotectin and of Gestational Age on IFABP Concentrations.Nutrients · 2025Article
- Characteristics of fecal calprotectin as an early marker for suspected necrotizing enterocolitis in newborns exclusively fed maternal breast milk: a case-control study.Proceedings (Baylor University. Medical Center) · 2024Article
- Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns.Children (Basel, Switzerland) · 2023Article
- Lipocalin-2 and calprotectin as stool biomarkers for predicting necrotizing enterocolitis in premature neonates.Pediatric research · 2022Article
- Emerging prediction methods for early diagnosis of necrotizing enterocolitis.Frontiers in medicine · 2022Review
- Time of Onset of Necrotizing Enterocolitis and Focal Perforation in Preterm Infants: Impact on Clinical, Surgical, and Histological Features.Frontiers in pediatrics · 2021Article
- Faecal calprotectin and gut microbiota do not predict enteropathy in very preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Hope on the horizon: promising novel therapies for necrotizing enterocolitis.Pediatric research · 2020Review
- Effect of Different Milk Diet on the Level of Fecal Calprotectin in Very Preterm Infants.Frontiers in pediatrics · 2020Article
- Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.Gastroenterology research and practice · 2019Review
- Calprotectin and necrotizing enterocolitis: it's not the assay, it's the definition.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- A comparative study of serum and fecal calprotectin levels in necrotizing enterocolitis.Jornal de pediatriaObservational
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCalprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC). STUDY
designStool calprotectin was measured in premature neonates without gastrointestinal pathology to create reference intervals. For comparison, levels from infants undergoing "rule out NEC" evaluations were plotted on these reference intervals.
resultsStool calprotectin reference intervals were created according to gestational age at birth and corrected gestational age. Levels during "rule out NEC" evaluations were more often above the upper reference interval with NEC vs. those without NEC.
conclusionsStools from preterm neonates have a higher range of calprotectin than stools from healthy term neonates. In evaluating preterm neonates for NEC with stool calprotectin, a calprotectin upper reference interval that incorporates corrected gestational age best predicts the diagnosis of NEC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.