ArticleScientific reports2018
Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Biofilm Formation in ClinicalBioMed research international · 2026Article
- Relationship between antibiotic resistance and biofilm-forming capacity with RND efflux pumps expression in clinical Acinetobacter baumannii isolates.Archives of microbiology · 2025Article
- Naringenin as a Potent Natural Biofilm Inhibitor of Pseudomonas aeruginosa in Diabetic Foot Ulcers Through lasR Competitive Inhibition.Current microbiology · 2025Article
- Comparative study of phenotypic and genotypic expression of virulence factors in colonizing and pathogenic carbapenem resistant Acinetobacter baumannii (CRAB).BMC microbiology · 2025Article
- Correlation between antimicrobial resistance, biofilm formation, and virulence determinants in uropathogenic Escherichia coli from Egyptian hospital.Annals of clinical microbiology and antimicrobials · 2024Article
- Type IV Pilus-Mediated Inhibition ofMicrobiology spectrum · 2023Article
- Review
- Biofilms and efflux pump regulatory gene (Veterinary world · 2022Article
- Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro.BMC microbiology · 2022Article
- Biofilm formation is not an independent risk factor for mortality in patients withFrontiers in cellular and infection microbiology · 2022Article
- Convergence of Biofilm Formation and Antibiotic Resistance inFrontiers in medicine · 2022Review
- Foodborne ESKAPE Biofilms and Antimicrobial Resistance: lessons Learned from Clinical Isolates.Pathogens and global health · 2021Review
- MacAB-TolC Contributes to the Development ofFrontiers in microbiology · 2021Article
- Biofilm-Induced Antibiotic Resistance in ClinicalAntibiotics (Basel, Switzerland) · 2020Article
- Biofilm formation in Acinetobacter baumannii was inhibited by PAβN while it had no association with antibiotic resistance.MicrobiologyOpen · 2020Article
- Biofilm-Formation in Clonally Unrelated Multidrug-ResistantPathogens (Basel, Switzerland) · 2020Article
- Glycomics Microarrays Reveal Differential In Situ Presentation of the Biofilm Polysaccharide Poly-International journal of molecular sciences · 2020Article
- Is Polymicrobial Bacteremia an Independent Risk Factor for Mortality inJournal of clinical medicine · 2020Article
- Article
- Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii.Probiotics and antimicrobial proteins · 2019Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of biofilm formation on bacteraemic pneumonia caused by A. baumannii is unknown. We conducted a 4-year multi-center retrospective study to analyze 71 and 202 patients with A. baumannii bacteraemic pneumonia caused by biofilm-forming and non-biofilm-forming isolates, respectively. The clinical features and outcomes of patients were investigated. Biofilm formation was determined by a microtitre plate assay. The antimicrobial susceptibilities of biofilm-associated cells were assessed using the minimum biofilm eradication concentration (MBEC) assay. Whole-genome sequencing was conducted to identify biofilm-associated genes and their promoters. Quantitative reverse transcription polymerase chain reaction was performed to confirm the expression difference of biofilm-associated genes. There was no significant difference in the clinical characteristics or the outcomes between patients infected with biofilm-forming and non-biofilm-forming strains. Compared with non-biofilm-forming isolates, biofilm-forming isolates exhibited lower resistance to most antimicrobials tested, including imipenem, meropenem, ceftazidime, ciprofloxacin and gentamicin; however, the MBEC assay confirmed the increased antibiotic resistance of the biofilm-embedded bacteria. Biofilm-associated genes and their promoters were detected in most isolates, including the non-biofilm-forming strains. Biofilm-forming isolates showed higher levels of expression of the biofilm-associated genes than non-biofilm-forming isolates. The biofilm-forming ability of A. baumannii isolates might not be associated with worse outcomes in patients with bacteraemic pneumonia.
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