ReviewNature reviews. Neuroscience2018
Breathing matters.
Review in Nature reviews. Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 350 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
350 citing papers in PubMed, 2 syntheses or guidelines pooled it, 668 citations in OpenAlex.
- The genetic architecture of brainstem structures.Nature communications · 2025Pooled it
- Inconclusive evidence that breathing shapes pupil dynamics in humans: a systematic review.Pflugers Archiv : European journal of physiology · 2023Pooled it
- Effects of four weeks of inspiratory muscle training with different resistance modalities on pulmonary function and specialized athletic ability in synchronized swimmers: a randomised trial.Scientific reports · 2026Trial
- Mechanical power guided lung protective ventilation in acute respiratory failure using the VentCoach approach.Scientific reports · 2026Trial
- Brief structured respiration practices enhance mood and reduce physiological arousal.Cell reports. Medicine · 2023Trial
- Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Modeling synaptic interactions between mammalian breathing and swallowing central pattern generators.Biological cybernetics · 2026Article
- Effects of TPA023B, an α2/3/5GABAPsychopharmacology · 2026Article
- Amyloid beta plaque pathology induces chemosensory deficits and increases apnoeas in the 5XFAD mouse model of Alzheimer's disease.The Journal of physiology · 2026Article
- Whole-Brain Monosynaptic Inputs and Outputs of Corticotropin-Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice.CNS neuroscience & therapeutics · 2026Article
- μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.The Journal of physiology · 2026Article
- A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Potential mechanisms and functional significance of aperiodic neural activity.Nature human behaviour · 2026Review
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Pupil size as a sensitive marker of acute stress dynamics.Comprehensive psychoneuroendocrinology · 2026Article
- Theory and evidence of amplitude control by frequency detuning in a coupled neuronal oscillator system.PLoS computational biology · 2026Article
- Functional synaptic interactions and inhibitory circuitry of the pre-Bötzinger complex in the rhythmic slice.Journal of neurophysiology · 2026Article
- Insular routing to orbitofrontal cortex enables breathing awareness.Science advances · 2026Article
- Neural Control of Mastication: Ion-Channel Mechanisms in the Brainstem Central Pattern Generator.Brain sciences · 2026Review
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
290 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural and physiological outputs that are easy to directly measure. Key neural elements for generating breathing pattern are distinct, compact and form a network amenable to detailed interrogation, promising the imminent discovery of molecular, cellular, synaptic and network mechanisms that give rise to the behaviour. Coupled oscillatory microcircuits make up the rhythmic core of the breathing network. Primary among these is the preBötzinger Complex (preBötC), which is composed of excitatory rhythmogenic interneurons and excitatory and inhibitory pattern-forming interneurons that together produce the essential periodic drive for inspiration. The preBötC coordinates all phases of the breathing cycle, coordinates breathing with orofacial behaviours and strongly influences, and is influenced by, emotion and cognition. Here, we review progress towards cracking the inner workings of this vital core.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.