ArticleScientific reports2018
Research on oral microbiota of monozygotic twins with discordant caries experience - in vitro and in vivo study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries.Journal of translational medicine · 2025Article
- Animal models of oral infectious diseases.Frontiers in oral health · 2025Review
- Microbial Symphony: Navigating the Intricacies of the Human Oral Microbiome and Its Impact on Health.Microorganisms · 2024Review
- Article
- Rodent models for oral microbiome research: considerations and challenges- a mini review.Frontiers in oral health · 2024Review
- Gut microbial similarity in twins is driven by shared environment and aging.EBioMedicine · 2022Article
- Interferon-inducible protein, IFIX, has tumor-suppressive effects in oral squamous cell carcinoma.Scientific reports · 2021Article
- Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children.Diagnostics (Basel, Switzerland) · 2021Article
- Study of oral microorganisms contributing to non-carious cervical lesions via bacterial interaction and pH regulation.Journal of cellular and molecular medicine · 2021Article
- Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.Critical care (London, England) · 2020Article
- Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice.International journal of oral science · 2019Article
- Comparison of initial oral microbiomes of young adults with and without cavitated dentin caries lesions using an in situ biofilm model.Scientific reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral microbiome is potentially correlated with many diseases, such as dental caries, periodontitis, oral cancer and some systemic diseases. Twin model, as an effective method for studying human microbiota, is widely used in research of relationship between oral microbiota and dental caries. However, there were few researches focusing on caries discordant twins. In this study, in vitro assays were conducted combined with 16S rRNA sequencing analysis on oral microbiota sampled from twins who presented discordant caries experience and mice model was developed as well. Results showed that oral microbiota from caries-active twin possessed higher metabolic activity and produced more lactic production. 16S rRNA sequencing analysis showed that more than 80% of family taxa could be transferred into gnotobiotic-mice. Key caries-associated genera were significantly different between twins and the same difference in genus level could be found in mice as well (p < 0.05). This study suggested that oral microbiota of twins could be distinguished from each other despite the similarities in genetic make-up, living environment, and lifestyle. The difference in microbiota was applied to develop a mice model which may facilitate the investigation of core microbiota of dental caries.
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Registered trials
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