ArticleScientific reports2018
Significantly increased low shear rate viscosity, blood elastic modulus, and RBC aggregation in adults following cardiac surgery.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A Pulsatile Flow-Modulation Microfluidic Sensor for Simultaneous Monitoring of Red Blood Cell Aggregation and Viscosity-Sensitive Time Constant.Sensors (Basel, Switzerland) · 2026Article
- Micro Blood Flow-Resolved Rheometry.Micromachines · 2026Article
- Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation.Drug delivery · 2025Article
- Effects of regular exercise on blood rheology.Scientific reports · 2025Article
- Effect of Magnetite Nanoparticles on Human Blood Components.Bulletin of experimental biology and medicine · 2024Article
- Flow-induced "waltzing" red blood cells: Microstructural reorganization and the corresponding rheological response.Science advances · 2022Article
- Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow.Scientific reports · 2021Article
- Oral Microbiota Changes in Elderly Patients, an Indicator of Alzheimer's Disease.International journal of environmental research and public health · 2021Article
- Effect of Temperature and Flow Rate on the Cell-Free Area in the Microfluidic Channel.Membranes · 2021Article
- Patient and haemodynamic factors affecting intraoperative graft flow during coronary artery bypass grafting: an observational pilot study.Scientific reports · 2020Observational
- The Hemocompatibility of Nanoparticles: A Review of Cell-Nanoparticle Interactions and Hemostasis.Cells · 2019Review
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Open heart surgeries are common for treating ischemic and heart valve disease. During cardiac surgery, cardiopulmonary bypass (CPB) can temporarily take over the function of heart and lungs. However, elevated red blood cell (RBC) aggregation may lead to the common side-effects such as microinfarction. We investigated blood physical properties changes and the correlation between blood microstructure, viscoelastic response and biochemical changes following surgery with CPB. We examined shear-rate dependent blood viscosity, elasticity and RBC aggregate size in the pre-surgery disease state, post-surgery state and long-term recovery state of cardiac surgical patients. Within a week following surgery, the patient hematocrit was significantly lower due to CPB. Despite lower RBC concentration, the RBC aggregate shape became larger and more rounded, which is correlated to the elevated plasma fibrinogen related to systemic inflammatory response. During the same period, the hematocrit-adjusted low shear rate viscosity increased significantly, as did the yield stress, indicating more solid-like behavior for blood. Six months to one year later, all the physical and biochemical properties measured returned to baseline.
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