ArticleScientific reports2018
Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy.PLoS genetics · 2020Pooled it
- Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth.Human genetics · 2021Trial
- Prenatal fine particulate matter (PM₂.₅) exposure differentially impairs fetal skeletal and soft-tissue growth: a longitudinal study in rural Butajira, Ethiopia.Journal of exposure science & environmental epidemiology · 2026Article
- Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.medRxiv : the preprint server for health sciences · 2026Article
- A rapid review of genetic association studies of parent-of-origin effects and fetal growth.Molecular and cellular pediatrics · 2026Review
- Autism Heterogeneity Related to Preterm Birth: Multi-Ancestry Results From the Simons Foundation Powering Autism Research for Knowledge Sample.Biological psychiatry global open science · 2026Article
- Impact of Bariatric Surgery on Newborn Growth Parameters.International journal of pediatrics · 2026Article
- Association of Glucose-Dependent Insulinotropic Polypeptide Receptor Polymorphisms rs3848460 and rs3895874 with the Risk of Gestational Diabetes Mellitus.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Decomposition of longitudinal disparities: an application to the fetal growth-singletons study.Biostatistics (Oxford, England) · 2025Article
- Use of a Maternal Genetic Risk Score to Derive and Test a Genetically Customized Fetal Growth Curve.O&G open · 2025Article
- Effect of the COVID-19 lockdown in Shanghai on maternal and neonatal outcomes.BMC pregnancy and childbirth · 2025Article
- Obstetric Ultrasound Screening in Lebanon for Fetal Diagnosis and Associated Factors of Congenital Abnormalities.Children (Basel, Switzerland) · 2025Article
- Maternal parity modifies the association of birthweight polygenic score with fetal growth.Scientific reports · 2025Article
- Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice.Acta physiologica (Oxford, England) · 2025Article
- The Correlation of Calcium and Hemoglobin Level Among Pregnant Women in ≥35 Weeks with the Anthropometry of Newborn Babies.International journal of women's health · 2025Article
- In-utero exposure to PM2.5 and adverse birth outcomes in India: Geostatistical modelling using remote sensing and demographic health survey data 2019-21.PLOS global public health · 2025Article
- Article
- Sex dimorphic associations of Prader-Willi imprinted gene expressions in umbilical cord with prenatal and postnatal growth in healthy infants.World journal of pediatrics : WJP · 2025Article
- No relationship found between dental fluctuating asymmetry, birthweight, and birth term in two modern North American samples.American journal of human biology : the official journal of the Human Biology Council · 2024Article
Corrections and comments
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6 authors.
Funding
Abstract
Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC = 53%, HL = 57%, FL = 72%, EFW = 71%; p < 0.05). In contrast, shared environment explained most of phenotypic variations in fetal growth in the first trimester (AC = 50%, HL = 54%, FL = 47%, EFW = 54%; p < 0.05), suggesting that the first trimester presents an intervention opportunity for a more optimal early fetal growth. Genetic correlations between growth traits (range 0.34-1.00; p < 0.05) were strongest at the end of first trimester and declined with gestation, suggesting that different fetal growth measures are more likely to be influenced by the same genes in early pregnancy.
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