ArticleScientific reports2018
Discovery and functional characterisation of a luqin-type neuropeptide signalling system in a deuterostome.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.Nature communications · 2026Article
- Evolution of neurohormone function revealed by actions of kisspeptin-type peptides in an echinoderm.BMC biology · 2026Article
- Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology.PloS one · 2026Article
- Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction.BMC biology · 2025Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Review
- Localization of relaxin-like gonad-stimulating peptide expression in starfish reveals the gonoducts as a source for its role as a regulator of spawning.The Journal of comparative neurology · 2023Article
- Immunohistochemical localisation of vasopressin/oxytocin-type, corazonin-type and luqin-type neuropeptide expression in the starfish Asterias rubens using antibodies to the C-terminal region of precursor proteins.Cell and tissue research · 2023Article
- Article
- Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides.BMC biology · 2022Article
- Somatostatin-type and allatostatin-C-type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Discovery and functional characterization of neuropeptides in crinoid echinoderms.Frontiers in neuroscience · 2022Article
- Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism.Frontiers in endocrinology · 2022Article
- Article
- Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate.Open biology · 2020Article
- Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling.eLife · 2020Article
- Temporal Study of the Perturbation of Crustacean Neuropeptides Due to Severe Hypoxia Using 4-Plex Reductive Dimethylation.Journal of proteome research · 2020Article
- Function and Distribution of the Wamide Neuropeptide Superfamily in Metazoans.Frontiers in endocrinology · 2020Review
- Evolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling.Frontiers in neuroscience · 2020Review
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Neuropeptides are diverse and evolutionarily ancient regulators of physiological/behavioural processes in animals. Here we have investigated the evolution and comparative physiology of luqin-type neuropeptide signalling, which has been characterised previously in protostomian invertebrates. Phylogenetic analysis indicates that luqin-type receptors and tachykinin-type receptors are paralogous and probably originated in a common ancestor of the Bilateria. In the deuterostomian lineage, luqin-type signalling has been lost in chordates but interestingly it has been retained in ambulacrarians. Therefore, here we characterised luqin-type signalling for the first time in an ambulacrarian - the starfish Asterias rubens (phylum Echinodermata). A luqin-like neuropeptide with a C-terminal RWamide motif (ArLQ; EEKTRFPKFMRW-NH
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