ArticleScientific reports2018
A Meloidogyne incognita effector MiISE5 suppresses programmed cell death to promote parasitism in host plant.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- The root-knot nematode effector Mi1D08B targets a NINJA-family co-repressor to suppress jasmonate production and promote infection in soybean.The Plant journal : for cell and molecular biology · 2026Article
- Constitutive Level of Specialized Secondary Metabolites Affects Plant Phytohormone Response to Above- and Belowground Herbivores.Journal of chemical ecology · 2024Article
- Insights into the plant response to nematode invasion and modulation of host defense by plant parasitic nematode.Frontiers in microbiology · 2024Review
- Greater than the sum of their parts: an overview of the AvrRps4 effector family.Frontiers in plant science · 2024Review
- Article
- Characterization of FiveInternational journal of molecular sciences · 2022Article
- Effectors of Root-Knot Nematodes: An Arsenal for Successful Parasitism.Frontiers in plant science · 2021Review
- Analyses of the Root-Knot Nematode (Pathogens (Basel, Switzerland) · 2020Article
- Transcriptomic changes in the pre-parasitic juveniles of3 Biotech · 2020Article
- BSA-Seq Discovery and Functional Analysis of Candidate Hessian Fly (Frontiers in plant science · 2020Article
- Plant Immune Responses to Parasitic Nematodes.Frontiers in plant science · 2019Review
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root-knot nematodes (RKNs) are highly specialized parasites that interact with their host plants using a range of strategies. The esophageal glands are the main places where nematodes synthesize effector proteins, which play central roles in successful invasion. The Meloidogyne incognita effector MiISE5 is exclusively expressed within the subventral esophageal cells and is upregulated during early parasitic stages. In this study, we show that MiISE5 can be secreted to barley cells through infectious hyphae of Magnaporthe oryzae. Transgenic Arabidopsis plants expressing MiISE5 became significantly more susceptible to M. incognita. Inversely, the tobacco rattle virus (TRV)-mediated silence of MiISE5 decreased nematode parasitism. Moreover, transient expression of MiISE5 suppressed cell death caused by Burkholderia glumae in Nicotiana benthamiana. Based on transcriptome analysis of MiISE5 transgenic sample and the wild-type (WT) sample, we obtained 261 DEGs, and the results of GO and KEGG enrichment analysis indicate that MiISE5 can interfere with various metabolic and signaling pathways, especially the JA signaling pathway, to facilitate nematode parasitism. Results from the present study suggest that MiISE5 plays an important role during the early stages of parasitism and provides evidence to decipher the molecular mechanisms underlying the manipulation of host immune defense responses by M. incognita.
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