Evidence map›Paper›PMID 29739998›Full record

ArticleScientific reports2018

Infants' dietary arsenic exposure during transition to solid food.

Antonio J Signes-Pastor, Kathryn L Cottingham, Manus Carey, Vicki Sayarath, Thomas Palys, Andrew A Meharg, Carol L Folt, Margaret R Karagas

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03893721 (Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03893721 unknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital

TypeobservationalSponsorAssiut UniversityRan2019 to 2020Enrolled80ConditionsMalnutrition, Child, Arsenic Poisoning ChronicArmsarsenic exposure
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  6. Article
  7. Essential and Toxic Elements in Infant Cereal in Brazil: Exposure Risk Assessment.International journal of environmental research and public health · 2024
    Article
  8. Article
  9. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
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  12. Article
  13. Review
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  15. Article
  16. Article
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  19. Article
  20. Chronic dietary exposure to inorganic arsenic.EFSA journal. European Food Safety Authority · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Antonio J Signes-PastorDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr., 7927 Rubin Bldg., Lebanon, NH, 03756, USA. antonio.j.signes-pastor@dartmouth.edu.ORCID 0000-0003-4898-2480
Kathryn L CottinghamDepartment of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA.ORCID 0000-0003-3169-5047
Manus CareyInstitute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast, BT9 5BN, Northern Ireland, UK.
Vicki SayarathDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr., 7927 Rubin Bldg., Lebanon, NH, 03756, USA.
Thomas PalysDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr., 7927 Rubin Bldg., Lebanon, NH, 03756, USA.
Andrew A MehargInstitute for Global Food Security, Queen's University Belfast, David Keir Building, Malone Road, Belfast, BT9 5BN, Northern Ireland, UK.ORCID 0000-0003-2019-0449
Carol L FoltUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Dr., 7927 Rubin Bldg., Lebanon, NH, 03756, USA.
Dartmouth College · USQueen's University Belfast · GBUniversity of North Carolina at Chapel Hill · US

Funding

Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7M
NIEHS NIH HHS P01 ES022832NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

Early-life exposure to inorganic arsenic (i-As) may cause long-lasting health effects, but as yet, little is known about exposure among weaning infants. We assessed exposure before and during weaning and investigated the association between solid food intake and infants' urinary arsenic species concentrations. Following the recording of a comprehensive 3 day food diary, paired urine samples (pre- and post-weaning) were collected and analyzed for arsenic speciation from 15 infants participating in the New Hampshire Birth Cohort Study. Infants had higher urinary i-As (p-value = 0.04), monomethylarsonic acid (MMA) (p-value = 0.002), dimethylarsinic acid (DMA) (p-value = 0.01), and sum of arsenic species (i-As + MMA + DMA, p-value = 0.01) during weaning than while exclusively fed on a liquid diet (i.e., breast milk, formula, or a mixture of both). Among weaning infants, increased sum of urinary arsenic species was pairwise-associated with intake of rice cereal (Spearman's ρ = 0.90, p-value = 0.03), fruit (ρ = 0.70, p-value = 0.03), and vegetables (ρ = 0.86, p-value = 0.01). Our observed increases in urinary arsenic concentrations likely indicate increased exposure to i-As during the transition to solid foods, suggests the need to minimize exposure during this critical period of development.

Indexed as

Environmental ExposureWeaningArsenicArsenicalsArsenic PoisoningCacodylic AcidFemaleFoodHumansInfantMilk, HumanOryzaArsenicArsenicalsCacodylic Acidmonomethylarsonic acid

Identifiers

PMID29739998
PMCPMC5940663
OpenAlexW2802153177

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.