ArticleScientific reports2018
Assessing causal estimates of the association of obesity-related traits with coronary artery disease using a Mendelian randomization approach.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Mendelian randomization studies on coronary artery disease: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- The Effect of Obesity on Repolarization and Other ECG Parameters.Journal of clinical medicine · 2024Article
- Independent relevance of adiposity measures to coronary heart disease risk among 0.5 million adults in UK Biobank.International journal of epidemiology · 2023Article
- Effect of visceral adipose tissue mass on coronary artery disease and heart failure: A Mendelian randomization study.International journal of obesity (2005) · 2022Article
- Review
- Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases.Communications medicine · 2022Article
- Sex-Specific Causal Relations between Steroid Hormones and Obesity-A Mendelian Randomization Study.Metabolites · 2021Article
- Educational differences in mortality associated with central obesity: Decomposing the contribution of risk and prevalence.Social science research · 2020Article
- Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study.BMC cardiovascular disorders · 2020Article
- Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses.Korean circulation journal · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity-related traits have been associated with coronary artery disease (CAD) in observational studies, but these associations may be biased by confounding factors and reverse causation. In this study, we specifically conducted two-sample Mendelian randomization (MR) analyses to overcome these limitations and test the associations of obesity-related traits (other than body mass index (BMI)) (n = 322,154) with CAD (22,233 cases and 64,762 controls) by using summary-level data from previous studies. The methods utilized to estimate these associations included the inverse-variance weighted method, the weighted median method and MR-Egger regression. Our results supported causal effects of BMI, hip circumference (HC), waist circumference (WC), and waist-hip ratio (WHR) on CAD. The associations of BMI-adjusted HC and WC with CAD were reversed, unlike that of WHR. In MR analyses excluding overlapping single nucleotide polymorphisms (SNPs) from obesity-related traits, the associations of these traits with CAD were preserved. The associations of BMI-adjusted HC and WC with CAD require further investigation, as collider stratification may be occurring. Additionally, central adiposity (measured by WHR) separated from general adiposity (measured by BMI) and general adiposity might pose similar risks for CAD. In clinical practice, physicians should pay attention to the potential effects of different obesity-related traits on CAD.
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