ArticleScientific reports2018
Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Exploring the role of oxidative stress in retinal vein occlusion: an updated and comprehensive review on the pathophysiology and treatment perspectives.International ophthalmology · 2025Pooled it
- Effect of Circadian Blood Pressure Variations on Retinal Microvascular Structures: Optical Coherence Tomography Angiography Analysis with the Nighttime Divided into Subintervals (Retinal Dawn Pattern).Medicina (Kaunas, Lithuania) · 2025Article
- Close relationship between systemic blood pressure and intraocular pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Ocular Biometry Profile and Its Associations with Systemic and Demographic Factors in Thai Cataract Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Association between vascular comorbidity and glaucoma progression: A four-year observational study.Experimental and therapeutic medicine · 2021Article
- Impact of blood pressure control on retinal microvasculature in patients with chronic kidney disease.Scientific reports · 2020Article
- The Schlager mouse as a model of altered retinal phenotype.Neural regeneration research · 2020Article
- Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles.Oxidative medicine and cellular longevity · 2019Article
- A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply. In this study we showed the presence of increased wall:lumen ratio and wall area of the ophthalmic artery in rats with chronic hypertension in addition to failure of retinal autoregulation in response to acute modification of ocular perfusion pressure. Subsequently we found that in spite of dramatically increasing ocular perfusion pressure, chronic systemic hypertension failed to protect retinal structure and function from a rodent model of glaucoma.
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