Evidence map›Paper›PMID 29739982›Full record

ArticleScientific reports2018

Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.

Wilhelm Roell, Alexandra M Klein, Martin Breitbach, Torsten S Becker, Ashish Parikh, Jane Lee, Katrin Zimmermann, Shaun Reining, Beth Gabris, Annika Ottersbach and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Interstitial cells and arrhythmia.American journal of physiology. Cell physiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Implications for neutrophils in cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  11. Article
  12. Article
  13. Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  14. Article
  15. Article
  16. Identification of Cx43 variants predisposing to ventricular fibrillation in the acute phase of ST-elevation myocardial infarction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Glycogen synthase kinase 3 beta inhibitor SB216763 improves Kir2.1 expression after myocardia infraction in rats.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Wilhelm RoellDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany. wroell@uni-bonn.de.
Alexandra M KleinDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Martin BreitbachInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Torsten S BeckerInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Ashish ParikhDepartment of Medicine, Heart and Vascular Institute and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, School of Medicine, 3500 Terrace Street, S368 Scaife Hall, 15261, Pittsburgh, PA, USA.
Jane LeeDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4-018 Veterinary Research Tower, 14853-2703, Ithaca, NY, USA.
Katrin ZimmermannDepartment of Pharmacology and Toxicology, Biomedical Center, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Shaun ReiningDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4-018 Veterinary Research Tower, 14853-2703, Ithaca, NY, USA.
Beth GabrisDepartment of Medicine, Heart and Vascular Institute and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, School of Medicine, 3500 Terrace Street, S368 Scaife Hall, 15261, Pittsburgh, PA, USA.
Annika OttersbachDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Robert DoranDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4-018 Veterinary Research Tower, 14853-2703, Ithaca, NY, USA.
Britta EngelbrechtDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Miriam SchifferDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Kenichi KimuraDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Patricia FreitagInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Esther CarlsDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Caroline GeisenInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Georg D DuerrDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Philipp SasseInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Armin WelzDepartment of Cardiac Surgery, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Alexander PfeiferDepartment of Pharmacology and Toxicology, Biomedical Center, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.
Guy SalamaDepartment of Medicine, Heart and Vascular Institute and the McGowan Institute for Regenerative Medicine, University of Pittsburgh, School of Medicine, 3500 Terrace Street, S368 Scaife Hall, 15261, Pittsburgh, PA, USA.
Michael KotlikoffDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, T4-018 Veterinary Research Tower, 14853-2703, Ithaca, NY, USA.
Bernd K FleischmannInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany. bernd.fleischmann@uni-bonn.de.
University of Bonn · DECornell University · USLife & Brain (Germany) · DEUniversity of Pittsburgh · USMcGowan Institute for Regenerative Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ventricular tachycardia (VT) is the most common and potentially lethal complication following myocardial infarction (MI). Biological correction of the conduction inhomogeneity that underlies re-entry could be a major advance in infarction therapy. As minimal increases in conduction of infarcted tissue markedly influence VT susceptibility, we reasoned that enhanced propagation of the electrical signal between non-excitable cells within a resolving infarct might comprise a simple means to decrease post-infarction arrhythmia risk. We therefore tested lentivirus-mediated delivery of the gap-junction protein Connexin 43 (Cx43) into acute myocardial lesions. Cx43 was expressed in (myo)fibroblasts and CD45

Indexed as

Genetic TherapyAnimalsArrhythmias, CardiacCicatrixConnexin 43Disease Models, AnimalFibroblastsGenetic VectorsHEK293 CellsHumansLentivirusMiceMuscle CellsMyoblastsMyocardial InfarctionTachycardia, VentricularConnexin 43

Identifiers

PMID29739982
PMCPMC5940892
OpenAlexW2802759425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.