ArticleNature communications2018
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- Intercepting Methanimine for the Synthesis of Piperidine-BasedThe Journal of organic chemistry · 2025Article
- Prebiotic thiol-catalyzed thioamide bond formation.Geochemical transactions · 2024Article
- Constraints on the emergence of RNA through non-templated primer extension with mixtures of potentially prebiotic nucleotides.Nucleic acids research · 2024Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Thiophosphate photochemistry enables prebiotic access to sugars and terpenoid precursors.Nature chemistry · 2023Article
- Small-Molecule Organocatalysis Facilitates In Situ Nucleotide Activation and RNA Copying.Journal of the American Chemical Society · 2023Article
- Origin of biological homochirality by crystallization of an RNA precursor on a magnetic surface.Science advances · 2023Article
- Enzymatic Fischer-Tropsch-Type Reactions.Chemical reviews · 2023Review
- Model Atmospheric Aerosols Convert to Vesicles upon Entry into Aqueous Solution.ACS earth & space chemistry · 2023Article
- Azoles as Auxiliaries and Intermediates in Prebiotic Nucleoside Synthesis.Journal of the American Chemical Society · 2022Article
- Marine phosphate availability and the chemical origins of life on Earth.Nature communications · 2022Article
- On the origins of life's homochirality: Inducing enantiomeric excess with spin-polarized electrons.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Protometabolism as out-of-equilibrium chemistry.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Review
- Carbon dioxide photoreduction in prebiotic environments.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Review
- UV Transmission in Natural Waters on Prebiotic Earth.Astrobiology · 2022Article
- CThe journal of physical chemistry. A · 2022Article
- Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation.PLoS computational biology · 2022Article
- Origin of Life on Mars: Suitability and Opportunities.Life (Basel, Switzerland) · 2021Article
- In search of the RNA world on Mars.Geobiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
When considering life's aetiology, the first questions that must be addressed are "how?" and "where?" were ostensibly complex molecules, considered necessary for life's beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomolecules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of prebiotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.