Evidence map›Paper›PMID 29739936›Full record

ArticleNature communications2018

Supramolecular Kandinsky circles with high antibacterial activity.

Heng Wang, Xiaomin Qian, Kun Wang, Ma Su, Wei-Wei Haoyang, Xin Jiang, Robert Brzozowski, Ming Wang, Xiang Gao, Yiming Li and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Low-Symmetry Face-Capped Fe(II) Tetrahedra Through Anisotropic Ligand Extension.Angewandte Chemie (International ed. in English) · 2025
    Article
  2. Review
  3. Review
  4. Synthesis of an Fe(terpy-cage)RSC advances · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Biomedically Relevant Self-Assembled Metallacycles and Metallacages.Journal of the American Chemical Society · 2019
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Heng WangDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Xiaomin QianDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Kun WangSingle Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA, 30602, USA.ORCID http://orcid.org/0000-0002-4907-310X
Ma SuDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Wei-Wei HaoyangDepartment of Chemistry, Fudan University, Shanghai, 200433, China.
Xin JiangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China.
Robert BrzozowskiDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA.
Ming WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Jilin, 130012, China.
Xiang GaoCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Yiming LiDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA.
Bingqian XuSingle Molecule Study Laboratory, College of Engineering and Nanoscale Science and Engineering Center, University of Georgia, Athens, GA, 30602, USA.
Prahathees EswaraDepartment of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA.
Xin-Qi HaoCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan, 450001, China.
Weitao GongState Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning, 116024, China. wtgong@dlut.edu.cn.ORCID http://orcid.org/0000-0003-0896-8895
Jun-Li HouDepartment of Chemistry, Fudan University, Shanghai, 200433, China. houjl@fudan.edu.cn.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA. jianfengcai@usf.edu.
Xiaopeng LiDepartment of Chemistry, University of South Florida, Tampa, FL, 33620, USA. xiaopengli1@usf.edu.

Funding

Self-assembly of 2D metallo-supramolecules as a novel class of antimicrobial biomaterials via forming transmembrane channelsR01GM128037 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2018 to 2021
$1.1M
NIGMS NIH HHS R01 GM128037NIH HHS 1R01GM128037-01
6 · The paper itself

Abstract

Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2-G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352 Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialHydrophobic and Hydrophilic InteractionsLigandsMacromolecular SubstancesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicroscopy, Atomic ForceMicroscopy, Electron, TransmissionMolecular WeightNanostructuresProton Magnetic Resonance SpectroscopyStaphylococcal InfectionsAnti-Bacterial AgentsLigandsMacromolecular Substances

Identifiers

PMID29739936
PMCPMC5940903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.