ArticleNature communications2018
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
18.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 138 citations in OpenAlex.
- Hepatic Lipid Stress Drives Metabolic Dysfunction-Associated Steatohepatitis Progression through FTO O-GlcNAcylation-Induced m6A Demethylation of HRAS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bronchiolar adenoma-like lesions with atypical features beyond the classic morphological spectrum: integrating histomorphology and molecular profiles.The Journal of pathology · 2026Article
- Malignant adenomyoepithelioma withOncology letters · 2026Article
- A Rare Case of Adenomyoepithelioma of the Breast Complicated with Cyst Diagnosed by Preoperative Core Needle Biopsy: A Case Report.Surgical case reports · 2026Article
- Malignant adenomyoepithelioma of the breast with axillary metastasis: a case report in a patient undergoingFrontiers in oncology · 2026Article
- Clinicopathological, Genomic, and Transcriptomic Feature Analysis of Primary Adrenal Large B-cell Lymphoma: Insights Into Immune-privileged Sites.The American journal of surgical pathology · 2025Article
- Overexpression of TSG101 causes the development of adenosquamous mammary carcinoma.Breast cancer research : BCR · 2025Article
- Targeting malignant adenomyoepithelioma of the breast: clinical insights on multimodal therapy and disease-free survival.Discover oncology · 2025Article
- Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.NPJ breast cancer · 2025Review
- Molecular Basis of Breast Tumor Heterogeneity.Advances in experimental medicine and biology · 2025Review
- Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate?OncoTargets and therapy · 2025Article
- Adenoid cystic carcinoma of the Bartholin's gland is underpinned by MYB- and MYBL1- rearrangements.Gynecologic oncology · 2024Article
- Invasive Carcinoma With Skin Adnexal Trichilemmal Hair Follicular Differentiation Occurring in the Breast: A Case Report With Detailed Immunohistochemical and Molecular Analysis.International journal of surgical pathology · 2024Article
- Translational Aspects in Metaplastic Breast Carcinoma.Cancers · 2024Review
- Converging and evolving immuno-genomic routes toward immune escape in breast cancer.Nature communications · 2024Article
- Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterations.NPJ precision oncology · 2024Article
- Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway.Cell biology international · 2024Article
- Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma.Targeted oncology · 2023Review
- The Relevance of Common K-RAS Gene Mutations and K-RAS mRNA Expression with Clinicopathological Findings and Survival in Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer's Mice.Molecular neurobiology · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 7 institutions in 7 countries.
Felipe C GeyerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Anqi LiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Anastasios D PapanastasiouDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Alison SmithHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Pier SelenicaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Kathleen A BurkeDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Marcia EdelweissDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Huei-Chi WenDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Salvatore PiscuoglioDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-2686-2939
Anne M SchultheisDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Luciano G MartelottoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Fresia ParejaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Rahul KumarDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Alissa BrandesDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Dan FanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Thais BasiliDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Arnaud Da Cruz PaulaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
John R LozadaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0001-8953-4110
Pedro BlecuaDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Simone MuenstInstitute of Pathology and Medical Genetics, University Hospital Basel, 4031, Basel, Switzerland.
Achim A JungbluthDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Maria P FoschiniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Section of Bellaria Hospital, 40139, Bologna, Italy.
Hannah Y WenDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Edi BrogiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Juan PalazzoDepartment of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, 19107, USA.
Brian P RubinDepartment of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Charlotte K Y NgDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-6100-0026
Larry NortonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Zsuzsanna VargaInstitute of Surgical Pathology, University Hospital Zurich, 8091, Zurich, Switzerland.
Ian O EllisDepartment of Pathology, University of Nottingham, Nottingham, NG7 2RD, UK.
Emad A RakhaDepartment of Pathology, University of Nottingham, Nottingham, NG7 2RD, UK.
Sarat ChandarlapatyHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-4532-8053
Britta WeigeltDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. weigeltb@mskcc.org.
Jorge S Reis-FilhoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. reisfilj@mskcc.org.
Memorial Sloan Kettering Cancer Center · USUniversity of Nottingham · GBCleveland Clinic · USOspedale Bellaria · ITThomas Jefferson University Hospital · USUniversity Hospital of Basel · CHUniversity Hospital of Zurich · CH
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748NIH HHS P30CA008748
Abstract
Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas display PIK3CA or AKT1 activating mutations, ER-negative adenomyoepitheliomas harbor highly recurrent codon Q61 HRAS hotspot mutations, which co-occur with PIK3CA or PIK3R1 mutations. In two- and three-dimensional cell culture models, forced expression of HRAS
Indexed as
Genes, rasMutationAdenomyoepitheliomaBiomarkers, TumorBreastBreast NeoplasmsCadherinsCell DifferentiationCell Line, TumorClass I Phosphatidylinositol 3-KinasesDisease ProgressionEnzyme ActivationEpithelial CellsExome SequencingFemaleHumansBiomarkers, TumorCadherinsClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humanProto-Oncogene Proteins c-aktReceptors, Estrogen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.