Evidence map›Paper›PMID 29739901›Full record

ArticlemBio2018

Compositional and Functional Differences in the Human Gut Microbiome Correlate with Clinical Outcome following Infection with Wild-Type Salmonella enterica Serovar Typhi.

Yan Zhang, Arthur Brady, Cheron Jones, Yang Song, Thomas C Darton, Claire Jones, Christoph J Blohmke, Andrew J Pollard, Laurence S Magder, Alessio Fasano and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Broad systemic T cell immunity toFrontiers in immunology · 2026
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  5. Viroid-like colonists of human microbiomes.bioRxiv : the preprint server for biology · 2024
    Article
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  7. Review
  8. Review
  9. Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yan ZhangInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Arthur BradyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Cheron JonesInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yang SongInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Thomas C DartonOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Claire JonesOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Christoph J BlohmkeOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Andrew J PollardOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Laurence S MagderDepartment of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, Maryland, USA.
Alessio FasanoDepartment of Pediatrics, Mucosal Immunology and Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Marcelo B SzteinDepartment of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Claire M FraserInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA cmfraser@som.umaryland.edu.
University of Maryland, Baltimore · USOxford BioMedica (United Kingdom) · GBMassachusetts General Hospital · USUniversity of Oxford · GB

Funding

Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2009 to 2018
$27.8M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
NIAID NIH HHS R01 AI036525NIAID NIH HHS U19 AI082655Wellcome TrustWellcome Trust 092661
6 · The paper itself

Abstract

Insights into disease susceptibility as well as the efficacy of vaccines against typhoid and other enteric pathogens may be informed by better understanding the relationship between the effector immune response and the gut microbiota. In the present study, we characterized the composition (16S rRNA gene profiling) and function (RNA sequencing [RNA-seq]) of the gut microbiota following immunization and subsequent exposure to wild-type

Indexed as

Gastrointestinal MicrobiomeAdolescentAdultBacteriaFemaleHumansLongitudinal StudiesMaleMiddle AgedPhylogenySalmonella typhiTyphoid FeverTyphoid-Paratyphoid VaccinesYoung AdultTyphoid-Paratyphoid Vaccines16S rRNA gene profilingimmunizationmetatranscriptomicsmethanogensmicrobiomeSalmonellatyphoid disease

Identifiers

PMID29739901
PMCPMC5941076
OpenAlexW2800963190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.