Evidence map›Paper›PMID 29739870›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Pregnancy-Associated Plasma Protein-aa Regulates Photoreceptor Synaptic Development to Mediate Visually Guided Behavior.

Andrew H Miller, Hollis B Howe, Bryan M Krause, Scott A Friedle, Matthew I Banks, Brian D Perkins, Marc A Wolman

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Article
  10. Leveraging Zebrafish to Study Retinal Degenerations.Frontiers in cell and developmental biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Andrew H MillerDepartment of Integrative Biology.
Hollis B HoweDepartment of Integrative Biology.
Bryan M KrauseDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, and.ORCID 0000-0001-5203-0381
Scott A FriedleDepartment of Integrative Biology.
Matthew I BanksDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, and.ORCID 0000-0002-1936-7529
Brian D PerkinsDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195.ORCID 0000-0002-9348-6542
Marc A WolmanDepartment of Integrative Biology, mawolman@wisc.edu.ORCID 0000-0002-8929-779X
University of Wisconsin–Madison · USCleveland Clinic · USFaculty of Public Health · GBLaboratoire d’immunologie intégrative du cancer · FR

Funding

NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
Cilia Assembly and Transport in the Vertebrate RetinaR01EY017037 · NEI · TEXAS A&M UNIVERSITY · PI PERKINS, BRIAN D · 2006 to 2021
$5.5M
Cortico-thalamic mechanisms of anesthetic unconsciousnessR01GM116916 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BANKS, MATTHEW I, TONONI, GIULIO · 2016 to 2019
$1.8M
NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY017037NIGMS NIH HHS R01 GM116916NIGMS NIH HHS T32 GM007507
6 · The paper itself

Abstract

To guide behavior, sensory systems detect the onset and offset of stimuli and process these distinct inputs via parallel pathways. In the retina, this strategy is implemented by splitting neural signals for light onset and offset via synapses connecting photoreceptors to ON and OFF bipolar cells, respectively. It remains poorly understood which molecular cues establish the architecture of this synaptic configuration to split light-onset and light-offset signals. A mutant with reduced synapses between photoreceptors and one bipolar cell type, but not the other, could reveal a critical cue. From this approach, we report a novel synaptic role for

Indexed as

AnimalsElectrophysiological PhenomenaFemaleInsulin-Like Growth Factor IMetalloendopeptidasesPhotic StimulationPhotoreceptor Cells, VertebratePsychomotor PerformanceRetinal Bipolar CellsRetinal Cone Photoreceptor CellsRetinal Photoreceptor Cell Inner SegmentSynapsesZebrafishZebrafish ProteinsIGF1RA protein, zebrafishInsulin-Like Growth Factor IMetalloendopeptidasespappaa protein, zebrafishZebrafish ProteinsIGF1Pappaaphotoreceptorsynapsevisual behaviorzebrafish

Identifiers

PMID29739870
PMCPMC5977450
OpenAlexW2792265091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.