Evidence map›Paper›PMID 29739866›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D

Raajaram Gowrishankar, Paul J Gresch, Gwynne L Davis, Rania M Katamish, Justin R Riele, Adele M Stewart, Roxanne A Vaughan, Maureen K Hahn, Randy D Blakely

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Transient Suppression of Dopamine Transporter Palmitoylation by Methamphetamine: Implications for Transport Regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  10. Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  11. Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Raajaram GowrishankarDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.ORCID 0000-0002-2477-8648
Paul J GreschDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, and.ORCID 0000-0002-7020-010X
Gwynne L DavisDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Rania M KatamishDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, and.ORCID 0000-0002-2569-8236
Justin R RieleDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Adele M StewartDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Roxanne A VaughanDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58201.
Maureen K HahnDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, and.
Randy D BlakelyDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, rblakely@fau.edu.ORCID 0000-0002-2182-6966
Vanderbilt University · USCollege of Charleston · USUniversity of North Dakota · US

Funding

Program in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4M
KNOCK-IN MOUSE MODEL OF DOPAMINE DYSFUNCTION UNDERLYING TRAITS OF ADHDR01MH105094 · NIMH · VANDERBILT UNIVERSITY · PI BLAKELY, RANDY D. · 2014 to 2018
$1.9M
In Vivo Modeling of Heritable Dopamine Transporter Dysfunction Associated with Neuropsychiatric DisordersF31MH107132 · NIMH · VANDERBILT UNIVERSITY · PI DAVIS, GWYNNE LANE · 2015 to 2016
$56k
NIMH NIH HHS F31 MH107132NIMH NIH HHS R01 MH105094NIMH NIH HHS T32 MH065215
6 · The paper itself

Abstract

Disruptions of dopamine (DA) signaling contribute to a broad spectrum of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), addiction, bipolar disorder, and schizophrenia. Despite evidence that risk for these disorders derives from heritable variation in DA-linked genes, a better understanding is needed of the molecular and circuit context through which gene variation drives distinct disease traits. Previously, we identified the DA transporter (DAT) variant Val559 in subjects with ADHD and established that the mutation supports anomalous DAT-mediated DA efflux (ADE). Here, we demonstrate that region-specific contributions of D

Indexed as

PenetranceAnimalsAutoreceptorsDopamineDopamine Plasma Membrane Transport ProteinsGenetic VariationHomeostasisMaleMental DisordersMiceMice, TransgenicReceptors, Dopamine D2AutoreceptorsDopamineDopamine Plasma Membrane Transport ProteinsReceptors, Dopamine D2dopaminedopamine D2 autoreceptordopamine transporterneuropsychiatric disorders

Identifiers

PMID29739866
PMCPMC5990980
OpenAlexW2801046639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.