Evidence map›Paper›PMID 29739864›Full record

ArticleJournal of lipid research2018

Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR.

Frode Norheim, Thomas Bjellaas, Simon T Hui, Karthickeyan Chella Krishnan, Jakleen Lee, Sonul Gupta, Calvin Pan, Yehudit Hasin-Brumshtein, Brian W Parks, Daniel Y Li and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Frode NorheimDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Thomas BjellaasVITAS Analytical Services, Oslo, Norway.
Simon T HuiDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Karthickeyan Chella KrishnanDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Jakleen LeeDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Sonul GuptaDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Calvin PanDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Yehudit Hasin-BrumshteinDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Brian W ParksDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI.
Daniel Y LiDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Hai H BuiLilly Research Laboratories, Indianapolis, IN.
Marian MosierLilly Research Laboratories, Indianapolis, IN.
Yuping WuDepartment of Mathematics, Cleveland State University, Cleveland OH.
Adriana Huertas-VazquezDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
Stanley L HazenDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Thomas E GundersenVITAS Analytical Services, Oslo, Norway.
Margarete MehrabianDivision of Cardiology University of California at Los Angeles, Los Angeles, CA.
W H Wilson TangDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Andrea L HevenerDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California at Los Angeles, Los Angeles, CA.
Christian A DrevonVITAS Analytical Services, Oslo, Norway.
Aldons J LusisDivision of Cardiology University of California at Los Angeles, Los Angeles, CA JLusis@mednet.ucla.edu.ORCID 0000-0001-9013-0228
University of California, Los Angeles · USCleveland Clinic Lerner College of Medicine · USEli Lilly (United States) · USCleveland State University · USUniversity of Oslo · NOUniversity of Wisconsin–Madison · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAJUKANTA, PAIVI · 1985 to 2019
$50.2M
Sex Differences in the Metabolic SyndromeU54DK120342 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2018 to 2022
$7.6M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
Systems Approach to Unraveling the Genetic Basis of Heart FailureR01HL114437 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, MARIO C., KARMA, ALAIN S · 2013 to 2016
$4.7M
Diet, Gut Microbiota, and Heart FailureR01HL126827 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2016 to 2019
$3.1M
Dietary Choline, Gut Microbiota, and Susceptibility for Chronic Kidney DiseaseR01DK106000 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2015 to 2018
$2.8M
Systems Genetics Analysis of Gene-by-Environment Interactions in ObesityR00HL123021 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PARKS, BRIAN WESLEY · 2016 to 2018
$747k
Systems Genetics Analysis of Gene-by-Environment Interactions in ObesityK99HL123021 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARKS, BRIAN WESLEY · 2014 to 2015
$247k
NHLBI NIH HHS K99 HL123021NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS P20 HL113452NHLBI NIH HHS R00 HL123021NHLBI NIH HHS R01 HL114437NHLBI NIH HHS R01 HL126827NIDDK NIH HHS R01 DK106000NIDDK NIH HHS U54 DK120342
6 · The paper itself

Abstract

Elevated hepatic ceramide levels have been implicated in both insulin resistance (IR) and hepatic steatosis. To understand the factors contributing to hepatic ceramide levels in mice of both sexes, we have quantitated ceramides in a reference population of mice, the Hybrid Mouse Diversity Panel that has been previously characterized for a variety of metabolic syndrome traits. We observed significant positive correlations between Cer(d18:1/16:0) and IR/hepatic steatosis, consistent with previous findings, although the relationship broke down between sexes, as females were less insulin resistant, but had higher Cer(d18:1/16:0) levels than males. The sex difference was due in part to testosterone-mediated repression of ceramide synthase 6. One ceramide species, Cer(d18:1/20:0), was present at higher levels in males and was associated with IR only in males. Clear evidence of gene-by-sex and gene-by-diet interactions was observed, including sex-specific genome-wide association study results. Thus, our studies show clear differences in how hepatic ceramides are regulated between the sexes, which again suggests that the physiological roles of certain hepatic ceramides differ between the sexes.

Indexed as

DietSex CharacteristicsAnimalsCeramidesFemaleInsulin ResistanceLiverMaleMiceTestosteroneCeramidesTestosteroneanimal modelsdiabetesgenome-wide association studiesgonadectomyinsulin resistancelipidomicsmass spectrometrysex hormonessphingolipids

Identifiers

PMID29739864
PMCPMC6027922
OpenAlexW2799964476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.