Evidence map›Paper›PMID 29739863›Full record

ArticleJournal of lipid research2018

Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

Milena Schönke, Julie Massart, Juleen R Zierath

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Vanadium(IV)-chlorodipicolinate alleviates hepatic steatosis via the AMPK/PGC-1α/CPT1a axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  12. Reduced Diet-induced Thermogenesis in Apolipoprotein A-IV Deficient Mice.International journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Milena SchönkeDepartment of Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden.
Julie MassartDepartment of Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden.
Juleen R ZierathDepartment of Molecular Medicine and Surgery Karolinska Institutet, Stockholm, Sweden Juleen.zierath@ki.se.ORCID 0000-0001-6891-7497
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral tissues and contributes to the development of insulin resistance. In vivo assays to quantify whole-body lipid oxidation in mouse models of insulin resistance are lacking. We describe a method for assessing whole-body FA oxidation in vivo, as well as tissue-specific lipid uptake in conscious mice. The method relies on intravenous administration of [9,10-

Indexed as

AMP-Activated Protein KinasesAnimalsDiet, High-FatEpoxy CompoundsGene Expression RegulationLipid MetabolismMaleMiceMice, Inbred C57BLMuscle, SkeletalMutationAMP-Activated Protein KinasesEpoxy Compoundsetomoxirdiet effects/lipid metabolismfatty acids/oxidationmetabolic kinetics

Identifiers

PMID29739863
PMCPMC6027908
OpenAlexW2810948747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.