Evidence map›Paper›PMID 29739855›Full record

ArticleThe Journal of biological chemistry2018

Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future.

Gang Cheng, Monika Zielonka, Brian Dranka, Suresh N Kumar, Charles R Myers, Brian Bennett, Alexander M Garces, Luiz Gabriel Dias Duarte Machado, David Thiebaut, Olivier Ouari and 3 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
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  4. Cystinosis and Cellular Energy Failure: Mitochondria at the Crossroads.International journal of molecular sciences · 2026
    Review
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  6. Article
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  11. Review
  12. Article
  13. Article
  14. Small molecule probes for peroxynitrite detection.Redox biochemistry and chemistry · 2024
    Article
  15. Ten "Cheat Codes" for Measuring Oxidative Stress in Humans.Antioxidants (Basel, Switzerland) · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Gang ChengFrom the Department of Biophysics.
Monika ZielonkaFrom the Department of Biophysics.
Brian Drankathe Cell Analysis Division, Agilent Technologies, Santa Clara, California 95051.
Suresh N KumarDepartments of Pathology and.
Charles R MyersPharmacology and Toxicology, and.
Brian Bennettthe Department of Physics, Marquette University, Milwaukee, Wisconsin 53233, and.
Alexander M Garcesthe Department of Physics, Marquette University, Milwaukee, Wisconsin 53233, and.
Luiz Gabriel Dias Duarte Machadothe Department of Physics, Marquette University, Milwaukee, Wisconsin 53233, and.
David Thiebautthe Aix Marseille Univ, CNRS, ICR, UMR 7273, Marseille 13013, France.
Olivier Ouarithe Aix Marseille Univ, CNRS, ICR, UMR 7273, Marseille 13013, France.
Micael Hardythe Aix Marseille Univ, CNRS, ICR, UMR 7273, Marseille 13013, France.
Jacek ZielonkaFrom the Department of Biophysics.
Balaraman KalyanaramanFrom the Department of Biophysics, balarama@mcw.edu.ORCID 0000-0002-9180-8296
Medical College of Wisconsin · USCentre National de la Recherche Scientifique · FRMarquette University · USAgilent Technologies (United States) · US

Funding

Chemoprevention of Lung Cancer with Mitochondria-Targeted HonokiolR01CA208648 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KALYANARAMAN, BALARAMAN, YOU, MING · 2017 to 2021
$3.1M
Targeting pancreatic cancer energy metabolism, tumor growth, and metastasisU01CA178960 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MICHAEL B, KALYANARAMAN, BALARAMAN · 2014 to 2018
$2.6M
NCI NIH HHS R01 CA208648NCI NIH HHS U01 CA178960
6 · The paper itself

Abstract

Reactive oxygen and nitrogen species (ROS/RNS) such as superoxide (O

Indexed as

Molecular Probe TechniquesAconitate HydrataseCell LineElectron Transport Complex IElectron Transport Complex IIIEnergy MetabolismEnzyme InhibitorsHumansMitochondriaOxidation-ReductionOxidative StressReactive Oxygen SpeciesSuperoxidesAconitate HydrataseElectron Transport Complex IElectron Transport Complex IIIEnzyme InhibitorsReactive Oxygen SpeciesSuperoxidesbioenergeticselectron paramagnetic resonance (EPR)low-temperature EPRmitochondrial oxidantsperoxiredoxinradical scavengersreactive oxygen species (ROS)redox probessuperoxide ionthiol-specific antioxidant enzymes

Identifiers

PMID29739855
PMCPMC6028982
OpenAlexW2800656602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.