ArticleJournal of the American Society of Nephrology : JASN2018
Interleukin-1
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In one paragraph
Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
142 citing papers in PubMed, 2 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function.Communications biology · 2023Pooled it
- Key Genetic Components of Fibrosis in Diabetic Nephropathy: An Updated Systematic Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Lactate-lactylation circuitry in kidney fibrosis: cellular crosstalk from tubular metabolic reprogramming to macrophage effector functions.Seminars in immunopathology · 2026Review
- Endothelial cell-specific knockout of ATG5 ameliorates inflammation and renal fibrosis by regulating pyroptosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- A heterobifunctional IRAK4-targeting degrader impairs myddosome signaling in acute kidney injury and ameliorates kidney fibrosis.Communications biology · 2026Article
- Induction of fibrosis in human kidney organoids delineates mechanisms and therapeutic targets of fibrotic kidney disease.Stem cell research & therapy · 2026Article
- Article
- Microenvironment optimization enables kidney organoid longevity with epithelial-endothelial joint basement membrane formation.bioRxiv : the preprint server for biology · 2026Article
- IL1β is induced in nephronophthisis but does not mediate kidney damage.Genes & diseases · 2026Article
- Renal allograft interstitial fibrosis: multicellular interactions and therapeutic strategies.Frontiers in immunology · 2026Review
- IL‑1 receptor antagonism attenuates renal fibrosis via RNF182‑driven MFN2 destabilization and mitochondrial dysfunction.Cell death discovery · 2025Article
- Modeling kidney fibrosis and tubular regeneration in iPSC-derived kidney organoids.Stem cell research & therapy · 2025Article
- Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression.Renal failure · 2025Review
- Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4/MyD88/NF-κB/NLRP3 pathway.Renal failure · 2025Article
- Fetuin-A and Heme Oxygenase 1 as Potential New Markers in the Diagnosis of Diabetic Kidney Disease.International journal of molecular sciences · 2025Review
- iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis.Stem cell research & therapy · 2025Article
- Low-intensity pulsed ultrasound stimulation to treat renal fibrosis through inhibiting tubular IL-1R.JCI insight · 2025Article
- PRDM16 acts as a therapeutic downstream target of TGF-β signaling in chronic kidney disease.JCI insight · 2025Article
- Mesenchymal stromal cell-derived membrane particles suppress kidney fibrosis.Stem cell research & therapy · 2025Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 3 countries.
Dario R LemosRenal Division, Brigham and Women's Hospital, Boston, Massachusetts; dlemos@bwh.harvard.edu.
Michael McMurdoResearch and Development, Biogen, Cambridge, Massachusetts.
Gamze KaracaResearch and Development, Biogen, Cambridge, Massachusetts.
Julia WilflingsederRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-0230-9349
Irina A LeafResearch and Development, Biogen, Cambridge, Massachusetts.
Navin GuptaRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Tomoya MiyoshiRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Koichiro SusaRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Bryce G JohnsonResearch and Development, Biogen, Cambridge, Massachusetts.
Kirolous SolimanRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Guanghai WangRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Ryuji MorizaneRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-0377-5667
Joseph V BonventreRenal Division, Brigham and Women's Hospital, Boston, Massachusetts.
Jeremy S DuffieldResearch and Development, Biogen, Cambridge, Massachusetts.
Brigham and Women's Hospital · USBiogen (United States) · US
Funding
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4MTRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8MKIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIRR01DK072381 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2005 to 2025
$8.6MMultiphoton Imaging of the Juxtaglomerular ApparatusR01DK064324 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JANOS PETI-PETERDI · 2004 to 2026
$8.4MMechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2MOrgan Design and Engineering Training Program (ODET Program)T32EB016652 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2014 to 2023
$3.5MKidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3MPericyte-endothelial cross talk in vascular stability after kidney injuryR01DK093493 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2012 to 2016
$2.5MKidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUG3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2017 to 2018
$2.0MKidney pericytes in vascular regeneration after injuryRC1DK087389 · NIDDK · UNIVERSITY OF WASHINGTON · PI DUFFIELD, JEREMY S · 2009 to 2010
$989kKidney Progenitor Cells in DiseaseR24DK094768 · NIDDK · UNIVERSITY OF WASHINGTON · PI GROSS, KENNETH W, PRUITT, STEVEN C · 2012 to 2012
$533kNCATS NIH HHS UG3 TR002155NCATS NIH HHS UH3 TR002155NIBIB NIH HHS T32 EB016652NIDDK NIH HHS R01 DK064324NIDDK NIH HHS R01 DK072381NIDDK NIH HHS R01 DK093493NIDDK NIH HHS R24 DK094768NIDDK NIH HHS R37 DK039773NIDDK NIH HHS RC1 DK087389NIDDK NIH HHS T32 DK007527
Abstract
PubMed holds no abstract for this paper.
Indexed as
Acute Kidney InjuryAnimalsAutophagyAzepinesCarrier ProteinsCell ProliferationCells, CulturedDisease ProgressionExtracellular MatrixFibrosisGlycolysisHumansInterleukin-1betaInterleukin-1 Receptor-Associated KinasesKidneyKidney Tubules, ProximalAzepinesCarrier ProteinsIL1B protein, humanInterleukin-1betaInterleukin-1 Receptor-Associated KinasesIRAK4 protein, humanIrak4 protein, mouse(+)-JQ1 compoundMembrane ProteinsMYC protein, humanMyc protein, mouseProto-Oncogene Proteins c-mycSequestosome-1 ProteinSQSTM1 protein, humanThyroid Hormone-Binding ProteinsThyroid HormonesTriazolesCell SignalingChronic inflammationinterstitial fibrosis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.