Evidence map›Paper›PMID 29739806›Full record

ArticleGenes & development2018

The surveillance of pre-mRNA splicing is an early step in

Martin A Newman, Fei Ji, Sylvia E J Fischer, Anthony Anselmo, Ruslan I Sadreyev, Gary Ruvkun

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

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  12. Conserved protein Pir2Nature communications · 2020
    Article
  13. Multigenerational Regulation of theAnnual review of genetics · 2019
    Review
  14. Article
  15. Article
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  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Martin A NewmanDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Fei JiDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Sylvia E J FischerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Anthony AnselmoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Gary RuvkunDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ALEXANDER A SOUKAS · 1994 to 2026
$31.6M
CONTROL OF THE C ELEGANS LINEAGE BY HETEROCHRONIC GENESR01GM044619 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI GARY B RUVKUN · 1991 to 2026
$14.5M
Novel Chemical Modifications of small RNAs in Caenorhabditis elegansF32GM101802 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI NEWMAN, MARTIN · 2012 to 2013
$101k
NIDDK NIH HHS P30 DK040561NIGMS NIH HHS F32 GM101802NIGMS NIH HHS R01 GM044619
6 · The paper itself

Abstract

RNAi pathways detect and silence foreign nucleic acids such as viruses as well as endogenous genes in many species. The phylogenetic profile across eukaryotes of proteins that mediate key steps in RNAi is correlated with the profiles of multiple mRNA splicing proteins and with intron number, suggesting that RNAi may surveil mRNA splicing to detect the divergent or absent introns of viruses. Here we examine the role of mRNA splicing in

Indexed as

RNA SplicingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression RegulationIntronsMutationRNA InterferenceRNA PrecursorsRNA, Small NuclearRNA Splicing FactorsSpliceosomesCaenorhabditis elegans ProteinsRNA PrecursorsRNA, Small NuclearRNA Splicing FactorsU1 small nuclear RNAU2 small nuclear RNAmRNA splicingRNAismall RNA biogenesisspliceosome

Identifiers

PMID29739806
PMCPMC6004069
OpenAlexW2802772466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.