ArticleJournal of the American Heart Association2018
Prevalence of Carotid Plaque in a 63- to 65-Year-Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01555411 (Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects), which is not on this map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Akershus Cardiac Examination 1950 Study - a Cohort Study on Cardio- and Cerebrovascular Disease in 62-65-year-old Subjects
Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Prevalence of Carotid Atherosclerosis in Adult Populations in Europe and North America (USA, Canada): A Systematic Review of Population-Based Studies (2015-2025).Diagnostics (Basel, Switzerland) · 2026Review
- Discriminating established cardiovascular disease using a novel multiterritory ultrasound plaque burden measure (wTPT): findings from the P-SONAR study.BMC cardiovascular disorders · 2026Article
- Association between a novel ultrasound-based measure of plaque burden and cardiovascular risk: the P-SONAR study.Quantitative imaging in medicine and surgery · 2026Article
- Association between socioeconomic variables and carotid plaque in middle-aged adults: data from the Akershus Cardiac Examination (ACE) 1950 Study.Open heart · 2026Article
- Frequency and risk factors of carotid atherosclerosis in patients with coronary artery disease.BMC cardiovascular disorders · 2026Article
- Physical activity and subclinical atherosclerosis in chronic Chagas disease: a cross-sectional study.Frontiers in medicine · 2026Article
- Healthy lifestyles and the incidence risk and time of carotid plaque: a nationwide cohort study.BMC public health · 2025Article
- Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis.International journal of molecular sciences · 2025Review
- Increased tau-induced inflammatory responses are associated with a greater degree of atherosclerosis in progressive supranuclear palsy.Frontiers in aging neuroscience · 2025Article
- Cervicocerebral Atherosclerosis Burden Increases Long-Term Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack.Journal of the American Heart Association · 2024Article
- Association of cervical atherosclerosis on Doppler ultrasonography and postoperative delirium in patients undergoing spinal surgery: a single-center, retrospective, observational study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Observational
- Carotid Plaque Score for Stroke and Cardiovascular Risk Prediction in a Middle-Aged Cohort From the General Population.Journal of the American Heart Association · 2023Article
- Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2023Article
- Low-grade carotid artery stenosis is associated with progression of brain atrophy and cognitive decline. The SMART-MR study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Article
- Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals.Clinics (Sao Paulo, Brazil) · 2022Article
- Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.Heart and vessels · 2021Article
- Subclinical Carotid Artery Atherosclerosis and Cognitive Function: A Mini-Review.Frontiers in neurology · 2021Review
- Plasma linoleic acid levels and cardiovascular risk factors: results from the Norwegian ACE 1950 Study.European journal of clinical nutrition · 2020Article
- Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study).Cardiovascular ultrasound · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNew data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima-media thickness (cIMT) and their relation to cardiovascular risk factors in a middle-aged cohort from the general population. METHODS AND
resultsWe performed carotid ultrasound in 3683 participants who were born in 1950 and included in a population-based Norwegian study. Carotid plaque and cIMT were assessed according to the Mannheim Carotid Intima-Media Thickness and Plaque Consensus, and a carotid plaque score was used to calculate atherosclerotic burden. The participants were aged 63 to 65 years, and 49% were women. The prevalence of established cardiovascular disease was low (10%), but 62% had hypertension, 53% had hypercholesterolemia, 11% had diabetes mellitus, and 23% were obese. Mean cIMT was 0.73±0.11 mm, and atherosclerotic carotid plaques were present in 87% of the participants (median plaque score: 2; interquartile range: 3). Most of the cardiovascular risk factors, with the exception of diabetes mellitus, obesity and waist-hip ratio, were independently associated with the plaque score. In contrast, only sex, hypertension, obesity, current smoking, and cerebrovascular disease were associated with cIMT.
conclusionsWe found very high prevalence of carotid plaque in this middle-aged population, and our data support a greater association between cardiovascular risk factors and plaque burden, compared with cIMT. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01555411.
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