ReviewDeutsches Arzteblatt international2018
The Risks Associated With Obesity in Pregnancy.
Review in Deutsches Arzteblatt international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05475951 (Investigation of Gasdermin-D and Pannexin-1 in Fat and Placental Tissues in Pregnant Women With Obesity), which is not on this map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Gasdermin-D and Pannexin-1 in Fat and Placental Tissues in Pregnant Women With Obesity
Who cites it
68 citing papers in PubMed, 150 citations in OpenAlex.
- ACE2 downregulation contributes to adverse cardiovascular and reproductive outcomes in female mice on high-fat diet.American journal of physiology. Heart and circulatory physiology · 2026Article
- Large language models for generating longitudinal synthetic data in low-risk pregnancy care.Data in brief · 2026Article
- Detection of periodontopathogens in umbilical cord blood and their correlation with the maternal bacterial profile.BMC oral health · 2026Article
- Global Data From Great Ape Zoo Populations Confirm a High Prevalence of Overweight Individuals.American journal of primatology · 2026Article
- Maternal nitrate supplementation improves offspring cardiometabolic outcomes in obese pregnancies.Annals of medicine · 2025Article
- Comparison of pregnancy and neonatal outcomes before and after laparoscopic sleeve gastrectomy in women diagnosed with obesity.BMC pregnancy and childbirth · 2025Article
- Does Bariatric Surgery Affect Pregnancy in Women in the Childbearing Period? A Retrospective Single Center Study.Obesity surgery · 2025Article
- Reduction of Neonatal Macrosomia Rate of Infants Born to Overweight and Obese Women through Nutrition Counseling in Pregnancy - A One-arm Interventional Study.Geburtshilfe und Frauenheilkunde · 2025Article
- Influence of Overweight and Obesity on Bone Remodeling during Pregnancy.Research square · 2025Article
- Incidence and risk factors of postpartum urinary retention following cesarean section: a retrospective nationwide inpatient sample database study.BMC women's health · 2025Article
- The association between gestational diabetes and fear of childbirth: a longitudinal register study.BMC pregnancy and childbirth · 2024Article
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- Impact of high-fat diet on ovarian epigenetics: Insights from altered intestinal butyric acid levels.Heliyon · 2024Article
- Maternal obesity and placental function: impaired maternal-fetal axis.Archives of gynecology and obstetrics · 2024Review
- An Observational Study of Maternal and Perinatal Outcome in Preeclampsia Cases in a Tertiary Care Center.Cureus · 2024Article
- Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Obesity in prenatal medicine: a game changer?Archives of gynecology and obstetrics · 2024Review
- Assessment of women's needs, wishes and preferences regarding interprofessional guidance on nutrition in pregnancy - a qualitative study.BMC pregnancy and childbirth · 2024Article
- Metabolic syndrome predictive modelling in Bangladesh applying machine learning approach.PloS one · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately one-third of all women of childbearing age are overweight or obese. For these women, pregnancy is associated with increased risks for both mother and child.
methodsThis review is based on pertinent publications retrieved by a selective search of PubMed, with special attention to current population-based cohort studies, systematic reviews, meta-analyses, and controlled trials.
resultsObesity in pregnancy is associated with unfavorable clinical outcomes for both mother and child. Many of the risks have been found to depend linearly on the body-mass index (BMI). The probability of conception declines linearly, starting from a BMI of 29 kg/m2, by 4% for each additional 1 kg/m2 of BMI (hazard ratio 0.96, 95% confidence interval: [0.91; 0.99]). A 10% increase of pregravid BMI increases the relative risk of gestational diabetes and that of preeclampsia by approximately 10% each. A 5 kg/m2 increase of BMI elevates the relative risk of intrauterine death to 1.24 [1.18; 1.30]. An estimated 11% of all neonatal deaths can be attributed to the consequences of maternal overweight and obesity. Nonetheless, in most randomized controlled trials, nutritional and lifestyle interventions did not bring about any clinically relevant reduction in the incidence of gestational diabetes and fetal macrosomia.
conclusionThe risks associated with obesity in pregnancy cannot necessarily be influenced by intervention. Preventive measures aimed at normalizing body weight before a woman becomes pregnant are, therefore, all the more important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.