Observational studyBMC ophthalmology2018
Assessment of capillary dropout in the superficial retinal capillary plexus by optical coherence tomography angiography in the early stage of diabetic retinopathy.
Observational study in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Application of optical coherence tomography in clinical diagnosis.Journal of X-ray science and technology · 2019Pooled it
- Trial
- Multiparametric OCTA Biomarkers for Classifying Mild Diabetic Retinopathy: A Cross-Sectional Evaluation.Translational vision science & technology · 2026Article
- The Effect of Periodontitis Severity on Diabetic Retinopathy: An Optical Coherence Tomography Study.Diagnostics (Basel, Switzerland) · 2026Article
- A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).Eye (London, England) · 2025Review
- Using blood biomarkers and ophthalmological indicators of optical coherence tomography and angiography for the diagnosis of fundus lesions in patients with diabetes mellitus.Frontiers in clinical diabetes and healthcare · 2025Article
- Differential Capillary and Large Vessel Analysis Improves OCTA Classification of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2024Article
- Appearance of retinal arterial macroaneurysms in patients using swept-source optical coherence tomographic angiography.BMC ophthalmology · 2023Article
- Right versus left eye asymmetry of microvasculature in diabetes revealed by optical coherence tomography angiography.Scientific reports · 2023Article
- Enhanced Deep Learning Model for Classification of Retinal Optical Coherence Tomography Images.Sensors (Basel, Switzerland) · 2023Article
- Automated Diagnosis of Optical Coherence Tomography Angiography (OCTA) Based on Machine Learning Techniques.Sensors (Basel, Switzerland) · 2022Article
- Quantitative analysis of retinal microvascular changes in prediabetic and diabetic patients.Indian journal of ophthalmology · 2021Article
- Evaluation of retinal vessel density and foveal avascular zone measurements in patients with obstructive sleep apnea syndrome.International ophthalmology · 2021Article
- The Determination of Type 2 Diabetes Mellitus's Impact on the Density of Retinal Blood Vessels and the Choriocapillaris: Optical Coherence Tomography Angiography Study.Journal of ophthalmology · 2021Article
- Exploratory study of non-invasive, high-resolution functional macular imaging in subjects with diabetic retinopathy.International journal of ophthalmology · 2021Article
- Macular Vessel Density in Diabetic Retinopathy Patients: How Can We Accurately Measure and What Can It Tell Us?Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Portable, non-invasive video imaging of retinal blood flow dynamics.Scientific reports · 2020Article
- Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 1: Diabetic Retinopathy.Translational vision science & technology · 2020Article
- Optical Coherence Tomography Angiography Contributions in Classification of Nonproliferative Diabetic Retinopathy.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2020Article
- Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus.Investigative ophthalmology & visual science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess capillary dropout in the superficial retinal capillary plexus (SCP) by optical coherence tomography angiography (OCTA) in the early stage of diabetic retinopathy (DR).
methodsThis study was a cross-sectional observational study. Patients that underwent OCTA examinations in our hospital between November 2015 and May 2016 were included in the study. The subjects were divided into two groups: A) normal controls (41 eyes of 41 subjects) and B) the DR patients (49 eyes of 49 patients with mild non-proliferative DR (NPDR)). The retinal thickness and SCP vessel density were analyzed using built-in software in nine sections of the macular area; whole scan area; fovea; parafovea; and sub-sections of the parafovea, superior-hemi, inferior-hemi, temporal, superior, nasal, and inferior. The correlation between vessel density and retinal thickness was also analyzed.
resultsThe SCP density was significantly lower (P < 0.05) in mild NPDR patients than in normal controls in all areas, with the exception of the fovea (P > 0.05). In the parafovea, superior-hemi, inferior-hemi, temporal, and nasal sectors of group B, the SCP density was negatively correlated with the corresponding retinal thickness (P < 0.05). Specifically, as the SCP density decreased, retinal thickness increased.
conclusionsIn the early stage of NPDR, retinal capillary dropout and retinal thickness changes can be clearly captured and analyzed by OCTA. The results confirm a negative correlation between vessel density and retinal thickness in diabetic patients. This noninvasive technique could be applied for DR detection and monitoring. Further study with a larger sample size is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.