Evidence map›Paper›PMID 29739378›Full record

Trial reportBMC pulmonary medicine2018

Higher serum 25-hydroxyvitamin D concentrations are associated with active pulmonary tuberculosis in hospitalised HIV infected patients in a low income tropical setting: a cross sectional study.

Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Mhandire, Tsitsi Bandason, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Vitamin D receptorTherapeutic advances in infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cuthbert MusarurwaDepartment of Chemical Pathology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe. curtbertm@yahoo.com.ORCID http://orcid.org/0000-0001-8248-427X
Lynn Sodai ZijenahDepartment of Immunology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
Doreen Zvipo MhandireDepartment of Chemical Pathology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
Tsitsi BandasonBiomedical Research and Training Institute, Harare, Zimbabwe.
Kudakwashe MhandireDepartment of Chemical Pathology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
Maria Mary ChipitiDepartment of Immunology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
Marshall Wesley MunjomaDepartment of Obstetrics and Gynaecology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
Witmore Bayayi MujajiDepartment of Chemical Pathology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, Zimbabwe.
University of Zimbabwe · ZWBiomedical Research and Training Institute · ZW

Funding

African Training Program for Research in AIDS & TBU2RTW007367 · FIC · BIOMEDICAL RESEARCH &TRAINING INSTITUTE · PI MASON, PETER ROBERT · 2005 to 2014
$4.8M
European and Developing Countries Clinical Trials Partnership IP.0932040009FIC NIH HHS U2R TW007367Fogarty International Center 2U2RTW007367
6 · The paper itself

Abstract

backgroundThe inherent risk of developing tuberculosis (TB) in HIV- infected individuals is further enhanced by hypovitaminosis D. Interventions that offset HIV-associated immune deterioration potentially arrest disease progression and incidence of opportunistic infections including TB. Despite conflicting reports on association between vitamin D deficiency (VDD) and risk of TB, vitamin D (VD) supplementation remains a promising intervention.

methodsWe conducted a comparative cross-sectional study on 145 HIV

resultsOverall VDD prevalence in the cohort was 40.9% (95% CI: 35.1-46.8). Median serum 25(OH)D concentrations were significantly higher in HIV

conclusionsThe finding of an association between higher serum 25(OH) D concentrations and active PTB and TB-related mortality among hospitalised HIV-infected patients in the present study is at variance with the commonly reported association of hypovitaminosis and susceptibility to TB. Our findings though, are in concordance with a small pool of reports from other settings.

Indexed as

HIV InfectionsTuberculosis, PulmonaryVitamin D DeficiencyAdultAnti-Retroviral AgentsCross-Sectional StudiesDisease ProgressionFemaleHumansIncidenceLength of StayLipopolysaccharidesMaleOpportunistic InfectionsRisk FactorsUrinalysis25-hydroxyvitamin DAnti-Retroviral AgentslipoarabinomannanLipopolysaccharidesVitamin DVitaminscARTHIVHospital stayPulmonary tuberculosisVitamin D deficiency

Identifiers

PMID29739378
PMCPMC5941493
OpenAlexW2806438183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.