Evidence map›Paper›PMID 29739359›Full record

ArticleBMC medical genetics2018

Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy.

Patricia S Graham, Georgia Kaidonis, Sotoodeh Abhary, Mark C Gillies, Mark Daniell, Rohan W Essex, John H Chang, Stewart R Lake, Bishwanath Pal, Alicia J Jenkins and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Association betweenAging · 2021
    Pooled it
  3. Pooled it
  4. Higher diabetes genetic load in proliferative diabetic retinopathy in South India: The South Indian GeNetics of DiAbeTic Retinopathy (SIGNATR) study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Association between theOpen life sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Patricia S GrahamMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Georgia KaidonisDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Sotoodeh AbharyDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Mark C GilliesSave Sight Institute, Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia.
Mark DaniellDepartment of Ophthalmology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Rohan W EssexAcademic Unit of Ophthalmology, Australian National University, Canberra, Australia.
John H ChangSchool of Medical Sciences, University of NSW, Sydney, New South Wales, Australia.
Stewart R LakeDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Bishwanath PalMedical Retina Service, Moorfields Eye Hospital, London, UK.
Alicia J JenkinsNHMRC Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia.
Alex W HewittMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Ecosse L LamoureuxCentre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia.
Philip G HykinMedical Retina Service, Moorfields Eye Hospital, London, UK.
Nikolai PetrovskyDepartment of Endocrinology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Matthew A BrownInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.
Kathryn P BurdonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Kathryn.Burdon@utas.edu.au.ORCID 0000-0001-8217-1249
Flinders University · AUUniversity of Tasmania · AUMoorfields Eye Hospital · GBThe University of Sydney · AUAustralian National University · AUQueensland University of Technology · AUThe Royal Melbourne Hospital · AUThe University of Melbourne · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopathy (DR) have been described previously, but have been difficult to replicate between studies, which have often used composite phenotypes and been conducted in different populations. This study aims to identify genetic risk factors for DME and PDR as separate complications in Australians of European descent with type 2 diabetes.

methodsCaucasian Australians with type 2 diabetes were evaluated in a genome-wide association study (GWAS) to compare 270 DME cases and 176 PDR cases with 435 non-retinopathy controls. All participants were genotyped by SNP array and after data cleaning, cases were compared to controls using logistic regression adjusting for relevant covariates.

resultsThe top ranked SNP for DME was rs1990145 (p = 4.10 × 10

conclusionThis study has identified loci of interest for DME and PDR, two common ocular complications of diabetes. These findings require replication in other Caucasian cohorts with type 2 diabetes and larger cohorts will be required to identify genetic loci with statistical confidence. There is considerable overlap in the patient cohorts with each retinopathy subtype, complicating the search for genes that contribute to PDR and DME biology.

Indexed as

Polymorphism, Single NucleotideAgedAustraliaCase-Control StudiesChromosomes, Human, Pair 2Chromosomes, Human, Pair 5Diabetes Mellitus, Type 2Diabetic RetinopathyFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMacular EdemaMaleMiddle AgedProprotein Convertase 2MALRD1 protein, humanPCSK2 protein, humanProprotein Convertase 2Receptors, LDLDiabetes complicationsDiabetic retinopathyGeneticsGenome-wide association studyMacular edema

Identifiers

PMID29739359
PMCPMC5941644
OpenAlexW2807675842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.