Observational studyBMC pregnancy and childbirth2018
Changes in serum prolactin level during intracytoplasmic sperm injection, and effect on clinical pregnancy rate: a prospective observational study.
Observational study in BMC pregnancy and childbirth, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02292953 (Variation in Serum Prolactin Levels in Response to Ovum Pickup for Patients Undergoing ICSI & it's Effect on Pregnancy Rate), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Variation in Serum Prolactin Levels in Response to Ovum Pickup for Patients Undergoing ICSI & it's Effect on Pregnancy Rate
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Competence of Combined Low Dose of Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (CC) Versus Continued CC during Ovulation Induction in Women with CC-Resistant Polycystic Ovarian Syndrome: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Roles of estradiol levels on the day of human chorionic gonadotrophin administration in the live birth of patients with frozen embryo transfer.Journal of clinical laboratory analysis · 2020Trial
- Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy.BMC pregnancy and childbirth · 2025Article
- Re-embarking in ART while still breastfeeding: an unresolved question.Archives of gynecology and obstetrics · 2025Review
- Gene Expression Levels ofInternational journal of fertility & sterility · 2023Article
- Construction of the machine learning-based live birth prediction models for the first in vitro fertilization pregnant women.BMC pregnancy and childbirth · 2023Article
- Impact of Endocrine Disorders on IVF Outcomes: Results from a Large, Single-Centre, Prospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Serum concentrations of progesterone and prolactin as predictors of success in in vitro fertilization: A retrospective cohort study.JBRA assisted reproduction · 2023Article
- Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes-A Review of the Literature.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The association between serum prolactin levels and live birth rates in non-PCOS patients: A retrospective cohort study.PloS one · 2023Article
- Homocysteine Level Related to Age Is Associated With Embryo Quality in Women Who Had IVF With Diminished Ovarian Reserve.Frontiers in reproductive health · 2022Article
- Mildly Higher Serum Prolactin Levels Are Directly Proportional to Cumulative Pregnancy Outcomes inFrontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient hyperprolactinemia was proven to adversely affect the outcome of IVF. We aimed to identify changes in serum prolactin levels in patients undergoing ICSI, and to evaluate the effect of these changes on the clinical pregnancy rate.
methodsA prospective observational study included 90 patients scheduled for ICSI cycles. In each case 4 serum samples were collected during the cycle (midluteal, before ovum pick up procedure (OPU), 2 h after OPU, and before embryo transfer). Serum prolactin level was determined by immunoassay each time.
resultsThe sample collected 2 h after OPU had a mean difference of 25.8 ± 2.8 ng/ml compared to the basal serum prolactin (p < 0.01). In comparison to other samples, this highlighted a significant hyperprolactinemia occurring after OPU, and resolving before embryo transfer. No statistically significant difference between the different serum prolactin samples amongst the pregnant and non pregnant patients. There was a significant positive pearson correlation between the prolactin levels before OPU, and the presence of higher quality embryos (r = 0.274, p = 0.019).
conclusionIn normoprolactinemic women transient hyperprolactinemia is identified in patients undergoing ICSI, and it doesn't affect the clinical pregnancy rates. A positive correlation was identified between higher quality embryos, and serum prolactin level before OPU.
trial registrationClinicalTrials.gov Identifier: NCT02292953 , First received: November 10, 2014.
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