Evidence map›Paper›PMID 29739343›Full record

SynthesisBMC geriatrics2018

Gender difference in the effects of interleukin-6 on grip strength - a systematic review and meta-analysis.

Alexandra Mikó, László Pótó, Péter Mátrai, Péter Hegyi, Nóra Füredi, András Garami, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó and 6 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Alexandra MikóInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
László PótóInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Péter MátraiInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Nóra FürediDepartment of Anatomy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
András GaramiInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Anita IllésDivision of Gastroenterology, First Department of Internal Medicine, University of Pécs, Ifjúság út 13, Pécs, 7624, Hungary.
Margit SolymárInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Áron VinczeDivision of Gastroenterology, First Department of Internal Medicine, University of Pécs, Ifjúság út 13, Pécs, 7624, Hungary.
Márta BalaskóInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Gabriella PárDivision of Gastroenterology, First Department of Internal Medicine, University of Pécs, Ifjúság út 13, Pécs, 7624, Hungary.
Patrícia SarlósDivision of Gastroenterology, First Department of Internal Medicine, University of Pécs, Ifjúság út 13, Pécs, 7624, Hungary.
Judit BajorDivision of Gastroenterology, First Department of Internal Medicine, University of Pécs, Ifjúság út 13, Pécs, 7624, Hungary.
Judit TenkInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Ildikó RostásInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Erika PéterváriInstitute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary. erika.petervari@aok.pte.hu.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAging sarcopenia characterized by low muscle mass with low muscle strength affects men and women differently. The contribution of interleukin-6 (IL-6) to sarcopenia has been suggested based on a negative correlation between plasma IL-6 and muscle function described by some studies. However, no consensus regarding clinically relevant cut-off criteria has been reached. Another question arises whether pooling male and female data is an accurate way to determine the predictive value of IL-6 in sarcopenia. The present meta-analysis was designed to assess: (1) whether plasma IL-6 in aged populations in fact correlates negatively to muscle strength; (2) whether such a correlation exists both in men and in women; and (3) whether plasma IL-6 shows a gender difference in old age.

methodsWe applied the preferred reporting items for systematic review and meta-analysis protocols (PRISMA). We searched PubMed and Embase for papers that reported data on individuals over 65 without inflammatory diseases. We extracted either separate male and female data on plasma IL-6 along with at least one muscle parameter or correlation coefficient between plasma IL-6 and these parameters. Random effect models calculated with DerSimonian and Laird weighting methods were applied to analyze correlation coefficients and gender difference in plasma IL-6. Egger's test was used to assess the small study effect.

resultsTwenty articles out of 468 records identified were suitable for analyses. Plasma IL-6 correlates negatively with grip strength in mixed populations and also separately in men [- 0.25 with 95% confidence interval (CI): - 0.48, - 0.02] and in women (- 0.14 with 95% CI: - 0.24, - 0.03). However, contrary to expectations, men with better muscle condition have higher plasma IL-6 than women of similar age with worse muscle condition (plasma IL-6 male-female difference: 0.25 pg/mL with 95% CI: 0.15, 0.35).

conclusionThis is the first study to demonstrate that a higher predictive IL-6 cut-off level should be determined for aging sarcopenia in men than in women.

Indexed as

Hand StrengthAgedFemaleHumansInterleukin-6MaleMiddle AgedSarcopeniaSex FactorsInterleukin-6GenderGrip strengthInflammationInterleukin-6Sarcopenia

Identifiers

PMID29739343
PMCPMC5941705
OpenAlexW2806361617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.