ReviewCurrent opinion in immunology2018
Lipids hide or step aside for CD1-autoreactive T cell receptors.
Review in Current opinion in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Human CD1c-autoreactive T-cells recogniseeLife · 2026Article
- Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses.Biomolecules · 2025Review
- A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1cFrontiers in immunology · 2025Article
- Direct recognition of an intact foreign protein by an αβ T cell receptor.Nature communications · 2024Article
- Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells.Immunology and cell biology · 2024Review
- Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.The Journal of experimental medicine · 2023Article
- Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.Cell reports · 2022Article
- Engineering soluble T-cell receptors for therapy.The FEBS journal · 2021Review
- Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- CD1a selectively captures endogenous cellular lipids that broadly block T cell response.The Journal of experimental medicine · 2021Article
- CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.Science immunology · 2021Article
- Novel Molecular Insights into Human Lipid-Mediated T Cell Immunity.International journal of molecular sciences · 2021Review
- Human skin is colonized by T cells that recognize CD1a independently of lipid.The Journal of clinical investigation · 2021Article
- Review
- MHC Restriction: Where Are We Now?Viral immunology · 2020Article
- Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.Science immunology · 2020Article
- CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.European journal of immunology · 2019Article
- A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.Nature communications · 2019Article
- Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease.Frontiers in immunology · 2019Article
- Lipid-Reactive T Cells in Immunological Disorders of the Lung.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Peptide and lipid antigens are presented to T cells when bound to MHC or CD1 proteins, respectively. The general paradigm of T cell antigen recognition is that T cell receptors (TCRs) co-recognize an epitope comprised of the antigen and antigen presenting molecule. Here we review the latest studies in which T cells operate outside the co-recognition paradigm: TCRs can broadly contact CD1 itself, but not the carried lipid. The essential structural feature in these new mechanisms is a large 'antigen free' zone on the outer surface of certain antigen presenting molecules. Whereas peptides dominate the exposed surface of MHC-peptide complexes, all human CD1 proteins have a closed, antigen-free surface, which is known as the A' roof. These new structural models help to interpret recent biological studies of CD1 autoreactive T cells in vivo, which have now been broadly observed in studies on TCR-transgenic mice, healthy humans and patients with autoimmune disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.